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EFFECT OF CALCIUM TRISODIUM DTPA IN RATS WITH PUNCTURE WOUND CONTAMINATED BY 90Y-CHLORIDE
https://repo.qst.go.jp/records/43739
https://repo.qst.go.jp/records/43739471d05cb-00a0-4958-984f-b4fdcdd0e265
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-07-20 | |||||
| タイトル | ||||||
| タイトル | EFFECT OF CALCIUM TRISODIUM DTPA IN RATS WITH PUNCTURE WOUND CONTAMINATED BY 90Y-CHLORIDE | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Watanabe, Naoyuki
× Watanabe, Naoyuki× Tanada, Shuji× Sasaki, Yasuhito× 渡辺 直行× 棚田 修二× 佐々木 康人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa3DTPA) in a dese of 34.7 mol kg-1 as a function of its route of administration was investigated in rats with a puncture wound contaminated by 90Y-chloride at a concentration of 2.55 MBq kg-1. Approximately 60% of 90Y-chloride at a puncture wound was absorbed into the body of rats over 72 h post-puncture and radioactivity in gemoral bone increased during the timed-release of 90Y. Intravenous administration of CaNaDTPA (systemic treatment) at 15 min post-puncture reduced 90Y at a puncture wound and in bone up to 75.6 and 84.3% of controls, respectively. Direct infiltration of CaNaDTPA into a puncture wound site (local treatment) at 15 min post-punctre diminished radioactivity at the puncture wound and in bone up to 34.9 and 52.5% of controls, respectively. Thus, prompt local treatment may be effective for removing 90Y from a puncture wound and minimising 90Y-distribution to bone compared with systemic treatment. |
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| 書誌情報 |
Radiation Protection Dosimetry 巻 114, 号 4, p. 509-513, 発行日 2005-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0144-8420 | |||||
