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DNA DSB induced by iron ions in human fibroblasts: LET dependence and shielding efficiency
https://repo.qst.go.jp/records/43673
https://repo.qst.go.jp/records/4367316154041-7ec2-4ceb-848e-0c703b7991fe
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-06-02 | |||||
| タイトル | ||||||
| タイトル | DNA DSB induced by iron ions in human fibroblasts: LET dependence and shielding efficiency | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Esposito, G
× Esposito, G× Antonelli, Francesca× Belli, Mauro× Campa, A× Dini, Valentina× Furusawa, Yoshiya× Simone, Giustina× Sorrentino, Eugenio× Antonella, Tabocchini Maria× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This paper reports on DNA DSB induction in human fibroblasts by iron ions of different energies, namely 5, 1 GeV/u, 414 and 115 MeV/u, in absence or presence of different shields (PMMA, Al and Pb). Measure of DNA DSB was performed by calibrated Pulsed Field Gel Electrophoresis using the fragment counting method. The RBE–LET relationships for unshielded and shielded beams were obtained both in terms of dose average LET and of track average LET. Weak dependence on these parameters was observed for DSB induction. The shielding efficiency, evaluated by the ratio between the cross sections for unshielded and shielded beams, depends not only on the shield type and thickness, but also on the beam energy. Protection is only observed at high iron ions energy, especially at 5 GeV/u, where PMMA shield gives higher protection compared to Al or Pb shields of the same thickness expressed in g/cm2. | |||||
| 書誌情報 |
Advances in Space Research 巻 35, p. 243-248, 発行日 2005 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0273-1177 | |||||
