@article{oai:repo.qst.go.jp:00043673, author = {Esposito, G and Antonelli, Francesca and Belli, Mauro and Campa, A and Dini, Valentina and Furusawa, Yoshiya and Simone, Giustina and Sorrentino, Eugenio and Antonella, Tabocchini Maria and 古澤 佳也}, journal = {Advances in Space Research}, month = {}, note = {This paper reports on DNA DSB induction in human fibroblasts by iron ions of different energies, namely 5, 1 GeV/u, 414 and 115 MeV/u, in absence or presence of different shields (PMMA, Al and Pb). Measure of DNA DSB was performed by calibrated Pulsed Field Gel Electrophoresis using the fragment counting method. The RBE–LET relationships for unshielded and shielded beams were obtained both in terms of dose average LET and of track average LET. Weak dependence on these parameters was observed for DSB induction. The shielding efficiency, evaluated by the ratio between the cross sections for unshielded and shielded beams, depends not only on the shield type and thickness, but also on the beam energy. Protection is only observed at high iron ions energy, especially at 5 GeV/u, where PMMA shield gives higher protection compared to Al or Pb shields of the same thickness expressed in g/cm2.}, pages = {243--248}, title = {DNA DSB induced by iron ions in human fibroblasts: LET dependence and shielding efficiency}, volume = {35}, year = {2005} }