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Particle irradiation suppresses metastatic potential of cancer cells
https://repo.qst.go.jp/records/43672
https://repo.qst.go.jp/records/43672a3f10cd4-128d-4ecc-902d-d5fe6739199f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-06-02 | |||||
| タイトル | ||||||
| タイトル | Particle irradiation suppresses metastatic potential of cancer cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ogata, Toshiyuki
× Ogata, Toshiyuki× Tashima, Teruki× Kagawa, Kazufumi× Hishikawa, Yoshio× Takahashi, Yutaka× Kawaguchi, Atsuko× Suzumoto, Yuuko× Nojima, Kumie× Furusawa, Yoshiya× Matsuura, Nariaki× 手島 昭樹× 香川 一史× 菱川 良夫× 高橋 豊× 川口 敦子× 鈴本 祐子× 野島 久美恵× 古澤 佳也× 松浦 成昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Particle radiotherapy such as proton and carbon ion has been producing promising clinical results worldwide. The purpose of this study was to compare metastatic capabilities of malignant tumor cells after irradiation with photon, proton, and carbon ion beams to clarify their ion beam–specific biological effects. We examined the biological properties of highly aggressive HT1080 human fibrosarcoma cells to assess their metastatic processes in terms of cell adhesion capability to extracellular matrix, expression of integrins, cell migration, cell invasive capability, and matrix metalloproteinase-2 activity in vitro. We then assessed the metastatic capabilities of LM8 mouse osteosarcoma irradiated with carbon ion or photon beam in the syngeneic mice. Both proton and carbon ion irradiation decreased cell migration and invasion in a dose-dependent manner and strongly inhibited matrix metalloproteinase-2 activity. On the other hand, lower X-ray irradiation promoted cell migration and invasion concomitant with up-regulation of aVh3 integrin. For cancer cells treated with carbon ion irradiation, the number of pulmonary metastasis was decreased significantly in vivo. These findings suggest that particle irradiation suppresses metastatic potential even at lower dose, whereas photon irradiation promotes cell migration and invasive capabilities at lower dose level, and provide preclinical evidence that ion beam radiotherapy may be superior to conventional photon beam therapy in possible preventive effects on metastases of irradiated malignant tumor cells. | |||||
| 書誌情報 |
Cancer Research 巻 65, 号 1, p. 113-120, 発行日 2005-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0008-5472 | |||||
