@article{oai:repo.qst.go.jp:00043672,
 author = {Ogata, Toshiyuki and Tashima, Teruki and Kagawa, Kazufumi and Hishikawa, Yoshio and Takahashi, Yutaka and Kawaguchi, Atsuko and Suzumoto, Yuuko and Nojima, Kumie and Furusawa, Yoshiya and Matsuura, Nariaki and 手島 昭樹 and 香川 一史 and 菱川 良夫 and 高橋 豊 and 川口 敦子 and 鈴本 祐子 and 野島 久美恵 and 古澤 佳也 and 松浦 成昭},
 issue = {1},
 journal = {Cancer Research},
 month = {Jan},
 note = {Particle radiotherapy such as proton and carbon ion has been producing promising clinical results worldwide. The purpose of this study was to compare metastatic capabilities of malignant tumor cells after irradiation with photon, proton, and carbon ion beams to clarify their ion beam–specific biological effects. We examined the biological properties of highly aggressive HT1080 human fibrosarcoma cells to assess their metastatic processes in terms of cell adhesion capability to extracellular matrix, expression of integrins, cell migration, cell invasive capability, and matrix metalloproteinase-2 activity in vitro. We then assessed the metastatic capabilities of LM8 mouse osteosarcoma irradiated with carbon ion or photon beam in the syngeneic mice. Both proton and carbon ion irradiation decreased cell migration and invasion in a dose-dependent manner and strongly inhibited matrix metalloproteinase-2 activity. On the other hand, lower X-ray irradiation promoted cell migration and invasion concomitant with up-regulation of aVh3 integrin. For cancer cells treated with carbon ion irradiation, the number of pulmonary metastasis was decreased significantly in vivo. These findings suggest that particle irradiation suppresses metastatic potential even at lower dose, whereas photon irradiation promotes cell migration and invasive capabilities at lower dose level, and provide preclinical evidence that ion beam radiotherapy may be superior to conventional photon beam therapy in possible preventive effects on metastases of irradiated malignant tumor cells.},
 pages = {113--120},
 title = {Particle irradiation suppresses metastatic potential of cancer cells},
 volume = {65},
 year = {2005}
}