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Biological gain of carbon-ion radiotherapy for the early response of tumor growth delay and agains aerly response of skin reaction in mice
https://repo.qst.go.jp/records/43646
https://repo.qst.go.jp/records/43646185ff1ad-a544-4fd3-8221-49533448cc91
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-04-05 | |||||
| タイトル | ||||||
| タイトル | Biological gain of carbon-ion radiotherapy for the early response of tumor growth delay and agains aerly response of skin reaction in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ando, Koichi
× Ando, Koichi× Koike, Sachiko× Uzawa, Akiko× Takai, Nobuhiko× Fukawa, Takeshi× Furusawa, Yoshiya× Aoki, Mizuho× Miyato, Yasuyuki× 安藤 興一× 小池 幸子× 鵜澤 玲子× 高井 伸彦× 扶川 武志× 古澤 佳也× 青木 瑞穂× 宮戸 靖幸 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The biological effectiveness of carbon ions relative to γ rays (RBE) was compared between the tumor growth delay and an early skin reaction of syngeneic mice. The RBE was larger for a tumor than skin when irradiated with large doses of high-LET (linear energy transfer) carbon ions. The intra-track damage (a term of a linear quadratic model) of a tumor and skin increased equally with an increase of the LET, while the inter-track damage (β term) of skin alone increased with the LET. These data provide evidence that high-LET radiotherapy could achieve therapeutic gain by minimizing the difference in response to fractionated irradiation between the tumor and normal tissue. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 46, 号 1, p. 51-57, 発行日 2005-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
