@article{oai:repo.qst.go.jp:00043646, author = {Ando, Koichi and Koike, Sachiko and Uzawa, Akiko and Takai, Nobuhiko and Fukawa, Takeshi and Furusawa, Yoshiya and Aoki, Mizuho and Miyato, Yasuyuki and 安藤 興一 and 小池 幸子 and 鵜澤 玲子 and 高井 伸彦 and 扶川 武志 and 古澤 佳也 and 青木 瑞穂 and 宮戸 靖幸}, issue = {1}, journal = {Journal of Radiation Research}, month = {Mar}, note = {The biological effectiveness of carbon ions relative to γ rays (RBE) was compared between the tumor growth delay and an early skin reaction of syngeneic mice. The RBE was larger for a tumor than skin when irradiated with large doses of high-LET (linear energy transfer) carbon ions. The intra-track damage (a term of a linear quadratic model) of a tumor and skin increased equally with an increase of the LET, while the inter-track damage (β term) of skin alone increased with the LET. These data provide evidence that high-LET radiotherapy could achieve therapeutic gain by minimizing the difference in response to fractionated irradiation between the tumor and normal tissue.}, pages = {51--57}, title = {Biological gain of carbon-ion radiotherapy for the early response of tumor growth delay and agains aerly response of skin reaction in mice}, volume = {46}, year = {2005} }