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Effects of carbon-ion beams on human pancreatic cancer cell lines that differ in genetic status.
https://repo.qst.go.jp/records/43487
https://repo.qst.go.jp/records/4348752539fb2-33c0-432c-a5f1-d29462791a3e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-10-04 | |||||
| タイトル | ||||||
| タイトル | Effects of carbon-ion beams on human pancreatic cancer cell lines that differ in genetic status. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsui, Yoshifumi
× Matsui, Yoshifumi× Asano, Takehide× Kanmochi, Takashi× Iwakawa, Mayumi× Imai, Takashi× Ochiai, Takenori× 松井 芳文× 浅野 武秀× 岩川 眞由美× 今井 高志× 落合 武徳 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The relative biologic effectiveness (RBE) of carbon-ion beams at 3 different linear energy transfer (LET) values (13, 50, and 80 keV/microm) accelerated by the Heavy Ion Medical Accelerator in Chiba on human pancreatic cancer cell lines differing in genetic status was determined. The RBE values were calculated as D10, the dose (Gy) required to reduce the surviving fraction to 10%, relative to X-rays. We also investigated apoptosis and the relationship between D10 and the cell cycle checkpoint using morphologic examination and flow cytometry analysis, respectively. The RBE values calculated by the D10 values ranged from 1.16 to 1.77 for the 13-keV/microm beam and from 1.83 to 2.46 for the 80-keV/microm beam. A correlation between the D10 values of each cell line and intensity of G2/M arrest was observed. In contrast, LET values did not clearly correlate with induction of apoptosis. These results suggest that carbon-ion beam therapy is a promising modality. Elucidation of the mechanisms of G2/M arrest and apoptosis may provide clues to enhancing the effects of radiation on pancreatic cancer. | |||||
| 書誌情報 |
American Journal of Clinical Oncology 巻 27, p. 24-28, 発行日 2004-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0277-3732 | |||||
