@article{oai:repo.qst.go.jp:00043487,
 author = {Matsui, Yoshifumi and Asano, Takehide and Kanmochi, Takashi and Iwakawa, Mayumi and Imai, Takashi and Ochiai, Takenori and 松井 芳文 and 浅野 武秀 and 岩川 眞由美 and 今井 高志 and 落合 武徳},
 journal = {American Journal of Clinical Oncology},
 month = {Feb},
 note = {The relative biologic effectiveness (RBE) of carbon-ion beams at 3 different linear energy transfer (LET) values (13, 50, and 80 keV/microm) accelerated by the Heavy Ion Medical Accelerator in Chiba on human pancreatic cancer cell lines differing in genetic status was determined. The RBE values were calculated as D10, the dose (Gy) required to reduce the surviving fraction to 10%, relative to X-rays. We also investigated apoptosis and the relationship between D10 and the cell cycle checkpoint using morphologic examination and flow cytometry analysis, respectively. The RBE values calculated by the D10 values ranged from 1.16 to 1.77 for the 13-keV/microm beam and from 1.83 to 2.46 for the 80-keV/microm beam. A correlation between the D10 values of each cell line and intensity of G2/M arrest was observed. In contrast, LET values did not clearly correlate with induction of apoptosis. These results suggest that carbon-ion beam therapy is a promising modality. Elucidation of the mechanisms of G2/M arrest and apoptosis may provide clues to enhancing the effects of radiation on pancreatic cancer.},
 pages = {24--28},
 title = {Effects of carbon-ion beams on human pancreatic cancer cell lines that differ in genetic status.},
 volume = {27},
 year = {2004}
}