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Changes in the pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation: Comparison with gamma-ray Radiation
https://repo.qst.go.jp/records/43477
https://repo.qst.go.jp/records/434776cbdfda3-db89-42d3-88dd-f508f84ae3f2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-09-08 | |||||
| タイトル | ||||||
| タイトル | Changes in the pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation: Comparison with gamma-ray Radiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Obata, Takayuki
× Obata, Takayuki× Ando, Koichi× Koike, Sachiko× Oohira, Chisa× Yasuda, Hiroshi× Ikehira, Hiroo× Tanada, Shuji× Tsujii, Hirohiko× 小畠 隆行× 安藤 興一× 小池 幸子× 保田 浩志× 池平 博夫× 棚田 修二× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We performed dynamic MRI to reveal the characteristic gadopentetate dimeglumine (Gd-DTPA) uptake in carbon-ion irradiated tumor and compare it with photon irradiation. Fibrosarcomas in C3H mice legs were irradiated with either 16 Gy of carbon ions (74 keV/mm) or an equivalent dose (30 Gy) of Cs-137 gamma-rays. Dynamic MRI was performed 1 or 6 days after irradiation when the tumors showed an initial growth delay or incipient regrowth, respectively. The enhancement pattern was visualized by mapping the maximum enhanced time (Tmax), relative signal intensity maximum (SImax), and time delay of starting enhancement (Td). Significantly larger Tmax and Td values were observed in the tumors 1 day after carbon-ion irradiation than in the nonradiated tumors (No-R) and tumors 1 day after gamma-ray irradiation. Among the selected pixels in the tumors 6 days after carbon irradiation, 77% had Tmax values of less than 120 sec, significantly more than in the No-R group. The Tmax maps for the tumors irradiated with gamma-rays showed a similar tendency to the carbon-irradiated ones, and only a significant difference was obtained between tumors 1 and 6 days after irradiation. Tmax and Td in the carbon-ion irradiated tumors were different from those in the gamma-ray-irradiated tumors. These treatment-specific kinetics may be useful in predicting the therapeutic efficacy of carbon-ion treatment. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 45, 号 2, p. 261-267, 発行日 2004-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
