@article{oai:repo.qst.go.jp:00043477,
 author = {Obata, Takayuki and Ando, Koichi and Koike, Sachiko and Oohira, Chisa and Yasuda, Hiroshi and Ikehira, Hiroo and Tanada, Shuji and Tsujii, Hirohiko and 小畠 隆行 and 安藤 興一 and 小池 幸子 and 保田 浩志 and 池平 博夫 and 棚田 修二 and 辻井 博彦},
 issue = {2},
 journal = {Journal of Radiation Research},
 month = {Jun},
 note = {We performed dynamic MRI to reveal the characteristic gadopentetate dimeglumine (Gd-DTPA) uptake in carbon-ion irradiated tumor and compare it with photon irradiation. Fibrosarcomas in C3H mice legs were irradiated with either 16 Gy of carbon ions (74 keV/mm) or an equivalent dose (30 Gy) of Cs-137 gamma-rays. Dynamic MRI was performed 1 or 6 days after irradiation when the tumors showed an initial growth delay or incipient regrowth, respectively. The enhancement pattern was visualized by mapping the maximum enhanced time (Tmax), relative signal intensity maximum (SImax), and time delay of starting enhancement (Td). Significantly larger Tmax and Td values were observed in the tumors 1 day after carbon-ion irradiation than in the nonradiated tumors (No-R) and tumors 1 day after gamma-ray irradiation. Among the selected pixels in the tumors 6 days after carbon irradiation, 77% had Tmax values of less than 120 sec, significantly more than in the No-R group. The Tmax maps for the tumors irradiated with gamma-rays showed a similar tendency to the carbon-irradiated ones, and only a significant difference was obtained between tumors 1 and 6 days after irradiation. Tmax and Td in the carbon-ion irradiated tumors were different from those in the gamma-ray-irradiated tumors. These treatment-specific kinetics may be useful in predicting the therapeutic efficacy of carbon-ion treatment.},
 pages = {261--267},
 title = {Changes in the pharmacokinetics of Gd-DTPA in Experimental Tumors after Charged Particle Radiation: Comparison with gamma-ray Radiation},
 volume = {45},
 year = {2004}
}