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Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis
https://repo.qst.go.jp/records/43472
https://repo.qst.go.jp/records/43472a8329ed1-752f-4f10-b158-6a9a8c9ad389
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-08-30 | |||||
| タイトル | ||||||
| タイトル | Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Takeuchi, Sakae× Wakamatsu, Kazumasa× Ito, Shosuke× et.al× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study was designed to clarify the role of the agouti gene in the regulation of the proliferation and differentiation of mouse epidermal melanocytes using serum-free primary culture system of epidermal melanocytes from 0.5-day-old black (a/a; C57BL/10JHir) mice and its congenic, agouti (A/A; C57BL/10JHir-A/A) mice. There was no significant difference in the proliferation and differentiation of melanocytes between a/a and A/A mice. However, content of pheomelanin in culture media from A/A melanocytes was increased by L-tyrosine compared with a/a melanocytes. In addition, content of pheomelanin precursor, 5-S-cysteinyldopa in culture media from A/A melanocytes was dramatically increased by L-tyrosine. Moreover, pheomelanin content in the epidermis from 3.5- and 5.5-day-old A/A mice was much higher than a/a mice. The analysis using reverse transcrition-polymerase chain reaction of the A gene revealed that cultured keratinocytes and melanocytes did not express the A gene. Moreover, the A gene was expressed in the A/A dermis of 0.5-, 3.5- and 5.5-day-old mice, but not in the a/a dermis as well as in the A/A and a/a epidermis. These results suggest that A/A epidermal melanoblasts are influenced by the A gene from the dermis of neonatal mice, and are capable of synthesizing pheomelanin in the culture. Pheomelanin production in the epidermis from 3.5- and 5.5-day-old A/A mice may be induced by the expression of the agouti gene in the dermis. | |||||
| 書誌情報 |
Pigment Cell Research 巻 17, 号 5, p. 506-514, 発行日 2004-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0893-5785 | |||||
