{"created":"2023-05-15T14:33:31.021664+00:00","id":43472,"links":{},"metadata":{"_buckets":{"deposit":"ba68d06d-b5cd-4663-9fae-ea8abc3a337c"},"_deposit":{"created_by":1,"id":"43472","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43472"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043472","sets":["1"]},"author_link":["432291","432295","432290","432292","432294","432293"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"514","bibliographicPageStart":"506","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Pigment Cell Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The present study was designed to clarify the role of the agouti gene in the regulation of the proliferation and differentiation of mouse epidermal melanocytes using serum-free primary culture system of epidermal melanocytes from 0.5-day-old black (a/a; C57BL/10JHir) mice and its congenic, agouti (A/A; C57BL/10JHir-A/A) mice. There was no significant difference in the proliferation and differentiation of melanocytes between a/a and A/A mice. However, content of pheomelanin in culture media from A/A melanocytes was increased by L-tyrosine compared with a/a melanocytes. In addition, content of pheomelanin precursor, 5-S-cysteinyldopa in culture media from A/A melanocytes was dramatically increased by L-tyrosine. Moreover, pheomelanin content in the epidermis from 3.5- and 5.5-day-old A/A mice was much higher than a/a mice. The analysis using reverse transcrition-polymerase chain reaction of the A gene revealed that cultured keratinocytes and melanocytes did not express the A gene. Moreover, the A gene was expressed in the A/A dermis of 0.5-, 3.5- and 5.5-day-old mice, but not in the a/a dermis as well as in the A/A and a/a epidermis. These results suggest that A/A epidermal melanoblasts are influenced by the A gene from the dermis of neonatal mice, and are capable of synthesizing pheomelanin in the culture. Pheomelanin production in the epidermis from 3.5- and 5.5-day-old A/A mice may be induced by the expression of the agouti gene in the dermis.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0893-5785","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirobe, Tomohisa"}],"nameIdentifiers":[{"nameIdentifier":"432290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeuchi, Sakae"}],"nameIdentifiers":[{"nameIdentifier":"432291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakamatsu, Kazumasa"}],"nameIdentifiers":[{"nameIdentifier":"432292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Shosuke"}],"nameIdentifiers":[{"nameIdentifier":"432293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"432294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣部 知久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432295","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-08-30"},"publish_date":"2004-08-30","publish_status":"0","recid":"43472","relation_version_is_last":true,"title":["Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:26:54.110252+00:00"}