WEKO3
-
RootNode
アイテム
Rejoining of isochromatid breaks induced by heavy ions in G2-phase normal human fibroblasts.
https://repo.qst.go.jp/records/43469
https://repo.qst.go.jp/records/43469b0dc8c9e-1276-44da-bac4-9c27b1ccbad0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-08-26 | |||||
| タイトル | ||||||
| タイトル | Rejoining of isochromatid breaks induced by heavy ions in G2-phase normal human fibroblasts. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kawata, Tetsuya
× Kawata, Tetsuya× Durante, Marco× Furusawa, Yoshiya× George, Kerry× Ito, Hisao× Wu, Honglu× A, Cucinotta Francesca× 川田 哲也× 古澤 佳也× ジョージ ケリー× 伊東 久夫× ウー ホングル× クシノッタ フランク |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We reported previously that exposure of normal human fibroblasts in G2 phase of the cell cycle to high-LET radiation produces a much higher frequency of isochromatid breaks than exposure to gamma rays. We concluded that an increase in the production of isochromatid breaks is a signature of initial high-LET radiation-induced G2-phase damage. In this paper, we report the repair kinetics of isochromatid breaks induced by high-LET radiation in normal G2-phase human fibroblasts. Exponentially growing human fibroblasts (AG1522) were irradiated with gamma rays or energetic carbon (290 MeV/nucleon), silicon (490 MeV/nucleon), or iron (200 MeV/nucleon) ions. Prematurely condensed chromosomes were induced by calyculin A after different postirradiation incubation times ranging from 0 to 600 min. Chromosomes were stained with Giemsa, and aberrations were scored in cells at G2 phase. G2-phase fragments, the result of the induction of isochromatid breaks, decreased quickly with incubation time. The curve for the kinetics of the rejoining of chromatid-type breaks showed a slight upward curvature with time after exposure to 440 keV/microm iron particles, probably due to isochromatid-isochromatid break rejoining. The formation of chromatid exchanges after exposure to high-LET radiation therefore appears to be underestimated, because isochromatid-isochromatid exchanges cannot be detected. Increased induction of isochromatid breaks and rejoining of isochromatid breaks affect the overall kinetics of chromatid-type break rejoining after exposure to high-LET radiation. | |||||
| 書誌情報 |
Radiation Research 巻 156, 号 5, p. 598-602, 発行日 2001-11 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
Share
Cite as
Kawata, Tetsuya, Durante, Marco, Furusawa, Yoshiya, George, Kerry, Ito, Hisao, Wu, Honglu, A, Cucinotta Francesca, 川田 哲也, 古澤 佳也, ジョージ ケリー, 伊東 久夫, ウー ホングル, クシノッタ フランク, 2001, Rejoining of isochromatid breaks induced by heavy ions in G2-phase normal human fibroblasts.: 598–602 p.
Loading...
