{"created":"2023-05-15T14:33:30.888127+00:00","id":43469,"links":{},"metadata":{"_buckets":{"deposit":"70537e67-3b2c-475e-b139-edad62b0f126"},"_deposit":{"created_by":1,"id":"43469","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43469"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043469","sets":["1"]},"author_link":["432263","432262","432264","432266","432273","432269","432268","432265","432270","432272","432261","432271","432267"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"602","bibliographicPageStart":"598","bibliographicVolumeNumber":"156","bibliographic_titles":[{"bibliographic_title":"Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We reported previously that exposure of normal human fibroblasts in G2 phase of the cell cycle to high-LET radiation produces a much higher frequency of isochromatid breaks than exposure to gamma rays. We concluded that an increase in the production of isochromatid breaks is a signature of initial high-LET radiation-induced G2-phase damage. In this paper, we report the repair kinetics of isochromatid breaks induced by high-LET radiation in normal G2-phase human fibroblasts. Exponentially growing human fibroblasts (AG1522) were irradiated with gamma rays or energetic carbon (290 MeV/nucleon), silicon (490 MeV/nucleon), or iron (200 MeV/nucleon) ions. Prematurely condensed chromosomes were induced by calyculin A after different postirradiation incubation times ranging from 0 to 600 min. Chromosomes were stained with Giemsa, and aberrations were scored in cells at G2 phase. G2-phase fragments, the result of the induction of isochromatid breaks, decreased quickly with incubation time. The curve for the kinetics of the rejoining of chromatid-type breaks showed a slight upward curvature with time after exposure to 440 keV/microm iron particles, probably due to isochromatid-isochromatid break rejoining. The formation of chromatid exchanges after exposure to high-LET radiation therefore appears to be underestimated, because isochromatid-isochromatid exchanges cannot be detected. Increased induction of isochromatid breaks and rejoining of isochromatid breaks affect the overall kinetics of chromatid-type break rejoining after exposure to high-LET radiation.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawata, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"432261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Durante, Marco"}],"nameIdentifiers":[{"nameIdentifier":"432262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"432263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"George, Kerry"}],"nameIdentifiers":[{"nameIdentifier":"432264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hisao"}],"nameIdentifiers":[{"nameIdentifier":"432265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wu, Honglu"}],"nameIdentifiers":[{"nameIdentifier":"432266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A, Cucinotta Francesca"}],"nameIdentifiers":[{"nameIdentifier":"432267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川田 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ジョージ ケリー","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊東 久夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ウー ホングル","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"クシノッタ フランク","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"432273","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Rejoining of isochromatid breaks induced by heavy ions in G2-phase normal human fibroblasts.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Rejoining of isochromatid breaks induced by heavy ions in G2-phase normal human fibroblasts."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-08-26"},"publish_date":"2004-08-26","publish_status":"0","recid":"43469","relation_version_is_last":true,"title":["Rejoining of isochromatid breaks induced by heavy ions in G2-phase normal human fibroblasts."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:26:56.140423+00:00"}