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G2 chromatid damage and repair kinetics in normal human fibroblast cells exposed to low- or high-LET radiation
https://repo.qst.go.jp/records/43406
https://repo.qst.go.jp/records/43406ae9b66c6-bcc4-4117-8e8c-fef5eec00a69
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-06-10 | |||||
| タイトル | ||||||
| タイトル | G2 chromatid damage and repair kinetics in normal human fibroblast cells exposed to low- or high-LET radiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kawata, Tetsuya
× Kawata, Tetsuya× Ito, Hisao× Uno, Takashi× Saito, Masayoshi× Yamamoto, S× Furusawa, Yoshiya× Durante, Marco× George, Kerry× Wu, Honglu× A, Cucinotta Francesca× 川田 哲也× 伊東 久夫× 宇野 隆× 古澤 佳也× ジョージ ケリー× ウー ホングル× クシノッタ フランク |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation-induced chromosome damage can be measured in interphase using the Premature Chromosome Condensation (PCC) technique. With the introduction of a new PCC technique using the potent phosphatase inhibitor calyculin-A, chromosomes can be condensed within five minutes, and it is now possible to examine the early damage induced by radiation. Using this method, it has been shown that high-LET radiation induces a higher frequency of chromatid breaks and a much higher frequency of isochromatid breaks than low-LET radiation. The kinetics of chromatid break rejoining consists of two exponential components representing a rapid and a slow time constant, which appears to be similar for low- and high-LET radiations. However, after high-LET radiation exposures, the rejoining process for isochromatid breaks influences the repair kinetics of chromatid-type breaks, and this plays an important role in the assessment of chromatid break rejoining in the G2 phase of the cell cycle. | |||||
| 書誌情報 |
Cytogenetic and Genome Research 巻 104, p. 211-215, 発行日 2004 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1424-8581 | |||||
