@article{oai:repo.qst.go.jp:00043406,
 author = {Kawata, Tetsuya and Ito, Hisao and Uno, Takashi and Saito, Masayoshi and Yamamoto, S and Furusawa, Yoshiya and Durante, Marco and George, Kerry and Wu, Honglu and A, Cucinotta Francesca and 川田 哲也 and 伊東 久夫 and 宇野 隆 and 古澤 佳也 and ジョージ ケリー and ウー ホングル and クシノッタ フランク},
 journal = {Cytogenetic and Genome Research},
 month = {},
 note = {Radiation-induced chromosome damage can be measured in interphase using the Premature Chromosome Condensation (PCC) technique. With the introduction of a new PCC technique using the potent phosphatase inhibitor calyculin-A, chromosomes can be condensed within five minutes, and it is now possible to examine the early damage induced by radiation. Using this method, it has been shown that high-LET radiation induces a higher frequency of chromatid breaks and a much higher frequency of isochromatid breaks than low-LET radiation. The kinetics of chromatid break rejoining consists of two exponential components representing a rapid and a slow time constant, which appears to be similar for low- and high-LET radiations. However, after high-LET radiation exposures, the rejoining process for isochromatid breaks influences the repair kinetics of chromatid-type breaks, and this plays an important role in the assessment of chromatid break rejoining in the G2 phase of the cell cycle.},
 pages = {211--215},
 title = {G2 chromatid damage and repair kinetics in normal human fibroblast cells exposed to low- or high-LET radiation},
 volume = {104},
 year = {2004}
}