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Adaptive Response in Embryogenesis: V. Existence of Two Efficient Dose-Rate Ranges for 0.3Gy of Priming Irradiation to Adapt Mouse Fetures.
https://repo.qst.go.jp/records/43368
https://repo.qst.go.jp/records/43368a55c3039-b7ad-4f84-b91a-0d6133dde33a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-03-30 | |||||
| タイトル | ||||||
| タイトル | Adaptive Response in Embryogenesis: V. Existence of Two Efficient Dose-Rate Ranges for 0.3Gy of Priming Irradiation to Adapt Mouse Fetures. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Ohyama, Harumi× Shang, Yi× Tanaka, Kaoru× Aizawa, Shirou× Yukawa, Osami× Hayata, Isamu× 王 冰× 大山 ハルミ× 尚 奕× 田中 薫× 相澤 志郎× 湯川 修身× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radioadaptive response (AR) manifests an important phenomenon in radiobiology. Study of conditions essential for the induction of AR is of critical significance to understanding the novel biodefense mechanisms against the hazardous effects of irradiation. In our previous studies, the specific dose and timing of radiation for induction of AR were demonstrated in ICR mouse fetuses, namely, exposure of the fetuses on embryonic day 11 to a priming irradiation of 0.3 Gy significantly suppressed prenatal death and malformation induced by a challenging dose of irradiation on embryonic day 12. As a profound dose-rate effect has been observed in a variety of radiobiological phenomena, the dose-rate effect on the effectiveness of AR induction by a priming irradiation of 0.3 Gy administered to fetuses on embryonic day 11, was investigated in the range from 0.06 to 5.0 Gy/min. The occurrence of apoptosis in limb buds, incidences of prenatal death and digital defects, and postnatal mortality induced by a challenging dose of 3.5 Gy given at 1.8 Gy/min to the fetuses on embryonic day 12, were employed as biological endpoints. Unexpectedly, effective induction of AR was observed within two dose-rate ranges for the same dose of priming irradiation, namely, from 0.18 to 0.98 Gy/min and from 3.5 to 4.6 Gy/min, for reduction of the detrimental effect induced by a challenging dose of 3.5 Gy. While when the priming irradiation was delivered at a dose rate outside of these two ranges, among some of them being contrary even the elevated detrimental effects were observed. In general, neither a normal or reverse dose-rate effect was found in the dose-rate range tested. These results clearly indicated that the dose rate at which the priming irradiation was delivered played a crucial role in the induction of AR. This paper provides the first evidence for the existence of two dose-rate ranges for the same dose of priming irradiation to successfully induce AR in mouse fetuses. |
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| 書誌情報 |
Radiation Research 巻 161, p. 264-272, 発行日 2004 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
