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Altered expression of Tfg and Dap3 in Ikaros-defective T cell lymphomas induced by X-irradiation in B6C3F1 mice
https://repo.qst.go.jp/records/43345
https://repo.qst.go.jp/records/43345794cd54b-8025-4594-8733-42cae339cea9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-02-06 | |||||
| タイトル | ||||||
| タイトル | Altered expression of Tfg and Dap3 in Ikaros-defective T cell lymphomas induced by X-irradiation in B6C3F1 mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yasumura, Kyoko
× Yasumura, Kyoko× Sugimura, Isamu× Igarashi, Kazuei× Kakinuma, Shizuko× Nishimura, Mayumi× Doi, Masahiro× Shimada, Yoshiya× 安村 今日子× 柿沼 志津子× 西村 まゆみ× 土居 雅広× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ikaros is a Kruppel-type zinc finger protein that is essential for normal lymphocyte development and differentiation. Recently, it has been demonstrated that Ikaros is frequently inactivated in both human and mouse leukemias/lymphomas. Although this inactivation is thought to be involved in leukemogenesis, little is known about the molecular mechanisms that lead to neoplastic transformation. To identify genes that may be controlled by Ikaros, we performed differential display analysis of RNAs from 3T3-L1 cells that had been transfected with the Ikaros gene. Two cDNAs, the Trk-fused gene (Tfg) and death-associated protein 3 (Dap3) were upregulated in Ikaros-transfected cells. Expression of Tfg and Dap3 was consistently downregulated in radiation-induced T cell lymphomas that exhibited defective Ikaros expression. These results suggest that Tfg and Dap3 function downstream of Ikaros and may be involved in radiation-induced lymphomagenesis. | |||||
| 書誌情報 |
British Journal of Haematology 巻 124, 号 2, p. 179-185, 発行日 2004 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0007-1048 | |||||
