{"created":"2023-05-15T14:33:25.352843+00:00","id":43345,"links":{},"metadata":{"_buckets":{"deposit":"d21ce626-4880-45f0-be0f-b15e5eb0de5f"},"_deposit":{"created_by":1,"id":"43345","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43345"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043345","sets":["1"]},"author_link":["431146","431141","431138","431140","431145","431148","431139","431142","431149","431147","431143","431144"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"185","bibliographicPageStart":"179","bibliographicVolumeNumber":"124","bibliographic_titles":[{"bibliographic_title":"British Journal of Haematology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ikaros is a Kruppel-type zinc finger protein that is essential for normal lymphocyte development and differentiation.  Recently, it has been demonstrated that Ikaros is frequently inactivated in both human and mouse leukemias/lymphomas.  Although this inactivation is thought to be involved in leukemogenesis, little is known about the molecular mechanisms that lead to neoplastic transformation.  To identify genes that may be controlled by Ikaros, we performed differential display analysis of RNAs from 3T3-L1 cells that had been transfected with the Ikaros gene. Two cDNAs, the Trk-fused gene (Tfg) and death-associated protein 3 (Dap3) were upregulated in Ikaros-transfected cells.  Expression of Tfg and Dap3 was consistently downregulated in radiation-induced T cell lymphomas that exhibited defective Ikaros expression.  These results suggest that Tfg and Dap3 function downstream of Ikaros and may be involved in radiation-induced lymphomagenesis.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0007-1048","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yasumura, Kyoko"}],"nameIdentifiers":[{"nameIdentifier":"431138","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugimura, Isamu"}],"nameIdentifiers":[{"nameIdentifier":"431139","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Igarashi, Kazuei"}],"nameIdentifiers":[{"nameIdentifier":"431140","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"431141","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"431142","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Doi, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"431143","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"431144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安村 今日子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"431145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"431146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"431147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"土居 雅広","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"431148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"431149","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Altered expression of Tfg and Dap3 in Ikaros-defective T cell lymphomas induced by X-irradiation in B6C3F1 mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Altered expression of Tfg and Dap3 in Ikaros-defective T cell lymphomas induced by X-irradiation in B6C3F1 mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-02-06"},"publish_date":"2004-02-06","publish_status":"0","recid":"43345","relation_version_is_last":true,"title":["Altered expression of Tfg and Dap3 in Ikaros-defective T cell lymphomas induced by X-irradiation in B6C3F1 mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:28:24.781238+00:00"}