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Subcellular localization and molecular mechanisms of nuclear transport of multifunctional Ku70 and Ku80 proteins
https://repo.qst.go.jp/records/43284
https://repo.qst.go.jp/records/432840fa176d3-1480-4cf7-ac22-4e0c750c4a6b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-26 | |||||
| タイトル | ||||||
| タイトル | Subcellular localization and molecular mechanisms of nuclear transport of multifunctional Ku70 and Ku80 proteins | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koike, Manabu
× Koike, Manabu× Koike, Aki× 小池 学× 小池 亜紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Ku protein is a complex of two subunits, Ku70 and Ku80, and was originally identified as an autoantigen that is recognized by the sera of patients with autoimmune diseases. The Ku70 and Ku80 genes are evolutionarily conserved, and homologues were identified in a number of organisms. The Ku protein is a multifunctional protein in DNA repair, telomere maintenance, transcription regulation, replication, and V(D)J recombination. Although the mechanism underlying the regulation of all the diverse functions of Ku is still mysterious, recent studies suggest that the regulatory mechanism for heterodimerization and/or subcellular localization of Ku70 and Ku80 plays. At least in part, a key role in regulating the physiological function of Ku in vivo. In this review, we focus on the subcellular localization and the molecular mechanisms of nuclear transport of Ku70 and Ku80. | |||||
| 書誌情報 |
Recent Research Developments in Biophysics and Biochemistry 巻 3, p. 141-158, 発行日 2003 |
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| 出版者 | ||||||
| 出版者 | Research Signpost | |||||
