WEKO3
アイテム
Stem-cell leukemia: p53 deficiency mediated suppresion of leukemic differentiation in C3H/He myeloid leukemia
https://repo.qst.go.jp/records/43283
https://repo.qst.go.jp/records/432838b24a4de-40da-4083-b021-6d678e2ad018
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-26 | |||||
| タイトル | ||||||
| タイトル | Stem-cell leukemia: p53 deficiency mediated suppresion of leukemic differentiation in C3H/He myeloid leukemia | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshida, Kazuko
× Yoshida, Kazuko× Aizawa, Shirou× Watanabe, Keiko× Hirabayashi, Yoko× Inoue, Tohoru× 吉田 和子× 相澤 志郎× 渡辺 恵子× 平林 容子× 井上 達 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | C3H/He mice produce myeloid leukemias after whole body irradiation of 1-3Gy as compared with non-irradiated controls that produce fewer than 1% of leukemia [Radiation Research 127 (1991) 146]. Thus, p53-deficient C57BL/6 strain, a malignant lymphoma prone, was crossed back into C3H/He strain. Lethally irradiated wild-type mice to which p53-deficient bone marrow cells were transplanted (transplantation assay) showed dramatic change in the propensity of leukemia of myeloid lineages, the cells lacking CD3, Thy1.2, sIgM, B220, Mac-1, Gr-1, but being positive for c-Kit and CD44. Furthermore, transplanted mice subjected to 3Gy irradiation gave rise to a faster development of leukemia and a higher frequency of double-lineage leukemias than the non-irradiated control. | |||||
| 書誌情報 |
Leukemia Research 巻 26, p. 1085-1092, 発行日 2002 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0145-2126 | |||||
