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Effects of a human dose of Ca-DTPA on removal of plutonium in rats
https://repo.qst.go.jp/records/43231
https://repo.qst.go.jp/records/43231919f9117-0669-4723-b3a2-bfce405053e6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-05 | |||||
| タイトル | ||||||
| タイトル | Effects of a human dose of Ca-DTPA on removal of plutonium in rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukuda, Satoshi
× Fukuda, Satoshi× Yan, Xueming× Iida, Haruzo× 福田 俊× 飯田 治三 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of a daily recommended human dose (1 g per 70 kg body weight=30 mmol/kg) of calcium diethylentriaminepentaacetic acid (Ca-DTPA) on removal of plutonium from rats injected with different amounts of plutonium were examined. Sixty female wistar rats were preinjected with doses of 0.185, 0.37 and 3.7 x105 Bq/kg of plutonium as a nitrate, and half of the rats of each dose group were injected with 30 mmol/kg of Ca-DTPA for 3 days, beginning 1 h after plutonium injection on the first day. The 24-h urine and feces of rats were collected. The amount of urinary plutonium excretion in the Ca-DTPA groups was found to be significantly greater than that in the respective corresponding control groups at day 1-3. The amount of urinary plutonium excretion in the Ca-DTPA group at the 1st day was increased in response to the plutonium injected dose (correlation coefficient: r=0.628, vs. r=0.573 in the control group), that accumulated in the Ca-DTPA group for 3 days was r=0.800 vs. r=0.669 in the control group), while their rates of plutonium injected dose were decreased. Such findings were not obtained in the feces measurements. In conclusion, a human dose of Ca-DTPA chelation therapy enhances plutonium excretion as increasing plutonium intake, however the excreted rate of plutonium intake is decreased. | |||||
| 書誌情報 |
Japanese Journal of Health Physics 巻 37, p. 158-161, 発行日 2002-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0367-6110 | |||||
