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Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity
https://repo.qst.go.jp/records/43124
https://repo.qst.go.jp/records/43124578dd05f-e785-4358-a287-b51179c6b833
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-08-04 | |||||
| タイトル | ||||||
| タイトル | Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamada, Shigeru
× Yamada, Shigeru× Durante, Marco× Ando, Koichi× Furusawa, Yoshiya× Kawata, Tetsuya× Majima, Hideyuki× Tsujii, Hirohiko× 山田 滋× 安藤 興一× 古澤 佳也× 馬嶋 秀行× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The new methods of chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization was used to analyze chromosomal damage in peripheral blood mononuclear lymphocytes of patients undergoing radiation treatment for esophageal cancer with high-energy X-rays or accelerated carbon ions at the National Institute of Radiological Sciences(Chiba, Japan). Total number of aberrant cells correlated with radiation field size, but no correlation was found with acute toxity. A high frequency of complex-type exchanges were also recorded. This aberration type presented a high individual variability, and correlated well with the acute morbidity. Cytogenetic analysis by interphase chromosome painting is proposed as a useful tool for monitoring normal tissue effects during radiotherapy. | |||||
| 書誌情報 |
Cancer Letters 巻 150, p. 215-221, 発行日 2000 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0304-3835 | |||||
