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MATERIALS AND METHODS: The SAS cells transfected with mutant p53 gene (SAS/mp53) or a neo control gene (SAS/neo) were transplanted into the thigh of each nude mouse. By measuring the tumor weight (TW), tumor regrowth delay was evaluated when the relative tumor weight (RW) reached 5-fold that of the control group. Apoptosis was analyzed by immunohistochemical and ApopTag stainings. RESULTS: SAS/mp53 tumors were more resistant to X-ray irradiation than SAS/neo tumors, but not to C-beam irradiation. The relative biological effectiveness (RBE) of C-beams compared to X-rays was 2.1 in SAS/neo tumors and 2.6 in SAS/mp53 tumors. Apoptotic cells were more frequently observed in SAS/neo tumors than in SAS/mp53 tumors in X-ray irradiation but not in C-beam irradiation. CONCLUSION: The radiation-induced growth inhibition of transplanted SAS cells is suggested to be p53-dependent in X-ray irradiation but not in C-beam irradiation. C-beams are proposed as being useful for cancer radiation therapy regardless of p53 gene status.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0250-7005", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Asakawa, Isao"}], "nameIdentifiers": [{"nameIdentifier": "427876", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshimura, H"}], "nameIdentifiers": [{"nameIdentifier": "427877", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Akihisa"}], "nameIdentifiers": [{"nameIdentifier": "427878", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohnishi, Ken"}], "nameIdentifiers": [{"nameIdentifier": "427879", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakagawa, H"}], "nameIdentifiers": [{"nameIdentifier": "427880", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota, I"}], "nameIdentifiers": [{"nameIdentifier": "427881", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furusawa, Yoshiya"}], "nameIdentifiers": [{"nameIdentifier": "427882", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tamamoto, Tetsurou"}], "nameIdentifiers": [{"nameIdentifier": "427883", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohishi, H"}], "nameIdentifiers": [{"nameIdentifier": "427884", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oonishi, Takeo"}], "nameIdentifiers": [{"nameIdentifier": "427885", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "浅川 勇雄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "427886", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高橋 昭久", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "427887", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "大西 健", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "427888", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古澤 佳也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "427889", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "玉本 哲郎", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "427890", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "大西 武雄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "427891", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/42996", "pubdate": {"attribute_name": "公開日", "attribute_value": "2002-08-21"}, "publish_date": "2002-08-21", "publish_status": "0", "recid": "42996", "relation": {}, "relation_version_is_last": true, "title": ["Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status"], "weko_shared_id": -1}
Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status
https://repo.qst.go.jp/records/42996
https://repo.qst.go.jp/records/42996ec93678f-cadf-4efe-8ba4-e20d1aecd87e
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2002-08-21 | |||||
タイトル | ||||||
タイトル | Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Asakawa, Isao
× Asakawa, Isao× Yoshimura, H× Takahashi, Akihisa× Ohnishi, Ken× Nakagawa, H× Ota, I× Furusawa, Yoshiya× Tamamoto, Tetsurou× Ohishi, H× Oonishi, Takeo× 浅川 勇雄× 高橋 昭久× 大西 健× 古澤 佳也× 玉本 哲郎× 大西 武雄 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND AND PURPOSE: To test p53-dependency in radiation cancer therapy with X-rays (low-linear energy transfer (LET)) or carbon-ion (C-) beams (high-LET heavy ion), we analyzed the radiation-induced growth rate and apoptosis induction in human tongue carcinomas transplanted into nude mice. MATERIALS AND METHODS: The SAS cells transfected with mutant p53 gene (SAS/mp53) or a neo control gene (SAS/neo) were transplanted into the thigh of each nude mouse. By measuring the tumor weight (TW), tumor regrowth delay was evaluated when the relative tumor weight (RW) reached 5-fold that of the control group. Apoptosis was analyzed by immunohistochemical and ApopTag stainings. RESULTS: SAS/mp53 tumors were more resistant to X-ray irradiation than SAS/neo tumors, but not to C-beam irradiation. The relative biological effectiveness (RBE) of C-beams compared to X-rays was 2.1 in SAS/neo tumors and 2.6 in SAS/mp53 tumors. Apoptotic cells were more frequently observed in SAS/neo tumors than in SAS/mp53 tumors in X-ray irradiation but not in C-beam irradiation. CONCLUSION: The radiation-induced growth inhibition of transplanted SAS cells is suggested to be p53-dependent in X-ray irradiation but not in C-beam irradiation. C-beams are proposed as being useful for cancer radiation therapy regardless of p53 gene status. | |||||
書誌情報 |
Anticancer Research 巻 24, p. 2037-2043, 発行日 2002-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0250-7005 |