{"created":"2023-05-15T14:33:09.881472+00:00","id":42996,"links":{},"metadata":{"_buckets":{"deposit":"1636c564-cfd0-4cb4-aafe-2f42d667ac9b"},"_deposit":{"created_by":1,"id":"42996","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"42996"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00042996","sets":["1"]},"author_link":["427887","427878","427883","427886","427889","427876","427890","427880","427884","427888","427879","427882","427877","427891","427881","427885"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"2043","bibliographicPageStart":"2037","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Anticancer Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND AND PURPOSE: To test p53-dependency in radiation cancer therapy with X-rays (low-linear energy transfer (LET)) or carbon-ion (C-) beams (high-LET heavy ion), we analyzed the radiation-induced growth rate and apoptosis induction in human tongue carcinomas transplanted into nude mice. MATERIALS AND METHODS: The SAS cells transfected with mutant p53 gene (SAS/mp53) or a neo control gene (SAS/neo) were transplanted into the thigh of each nude mouse. By measuring the tumor weight (TW), tumor regrowth delay was evaluated when the relative tumor weight (RW) reached 5-fold that of the control group. Apoptosis was analyzed by immunohistochemical and ApopTag stainings. RESULTS: SAS/mp53 tumors were more resistant to X-ray irradiation than SAS/neo tumors, but not to C-beam irradiation. The relative biological effectiveness (RBE) of C-beams compared to X-rays was 2.1 in SAS/neo tumors and 2.6 in SAS/mp53 tumors. Apoptotic cells were more frequently observed in SAS/neo tumors than in SAS/mp53 tumors in X-ray irradiation but not in C-beam irradiation. CONCLUSION: The radiation-induced growth inhibition of transplanted SAS cells is suggested to be p53-dependent in X-ray irradiation but not in C-beam irradiation. C-beams are proposed as being useful for cancer radiation therapy regardless of p53 gene status.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0250-7005","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Asakawa, Isao"}],"nameIdentifiers":[{"nameIdentifier":"427876","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshimura, H"}],"nameIdentifiers":[{"nameIdentifier":"427877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Akihisa"}],"nameIdentifiers":[{"nameIdentifier":"427878","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohnishi, Ken"}],"nameIdentifiers":[{"nameIdentifier":"427879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakagawa, H"}],"nameIdentifiers":[{"nameIdentifier":"427880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ota, I"}],"nameIdentifiers":[{"nameIdentifier":"427881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"427882","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamamoto, Tetsurou"}],"nameIdentifiers":[{"nameIdentifier":"427883","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohishi, H"}],"nameIdentifiers":[{"nameIdentifier":"427884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oonishi, Takeo"}],"nameIdentifiers":[{"nameIdentifier":"427885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"浅川 勇雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 昭久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西 健","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427888","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"玉本 哲郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西 武雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427891","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-08-21"},"publish_date":"2002-08-21","publish_status":"0","recid":"42996","relation_version_is_last":true,"title":["Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:32:29.888239+00:00"}