WEKO3
アイテム
Significance of fractionated irradiation for the biological therapeutic gain of carbon ions
https://repo.qst.go.jp/records/42995
https://repo.qst.go.jp/records/42995234f2b4f-51d0-4876-b105-205668584bf9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-08-21 | |||||
| タイトル | ||||||
| タイトル | Significance of fractionated irradiation for the biological therapeutic gain of carbon ions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koike, Sachiko
× Koike, Sachiko× Ando, Koichi× Uzawa, Akiko× Takai, Nobuhiko× Fukawa, Takeshi× Furusawa, Yoshiya× Oohira, Chisa× Aoki, Mizuho× Monobe, Manami× Lee, Ryonfa× Suzuki, Masao× Nojima, Kumie× 小池 幸子× 安藤 興一× 鵜澤 玲子× 高井 伸彦× 扶川 武志× 古澤 佳也× 青木 瑞穂× 物部 真奈美× 李 玲華× 鈴木 雅雄× 野島 久美恵 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is well established that the RBE (relative biological effectiveness) for cell killing depends on LET (linear energy transfer), and that a maximum RBE is observed at ~150 keV/mm. However, the therapeutic gain depends on the ratio of the RBEs for the effects on the cancer cell population and the effects on normal tissues. The RBE of a given radiation quality depends on LET but also on dose, biological system and effect, and irradiation conditions. There is no data available to answer the question: which LET is suitable to improve the biological therapeutic gain of carbon ions? Here, we selected 3 different LET values of 290 MeV/u carbon ions, and compared the relative biological effectiveness between tumor-growth retardation and skin damage using a murine transplantable tumor. Larger RBE values for tumors after than the skin type were obtained when carbon-ions of intermediate LET were daily delivered for 2 through 5 fractions. The biological therapeutic gain would be high for the carbon-ion SOBP if the number of fractions were correctly selected in clinical trials. | |||||
| 書誌情報 |
Radiation Protection Dosimetry 巻 99, p. 405-408, 発行日 2002 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0144-8420 | |||||
