{"created":"2023-05-15T14:33:09.837589+00:00","id":42995,"links":{},"metadata":{"_buckets":{"deposit":"cb1f48b1-ba01-4390-95cd-27b40c1d46d6"},"_deposit":{"created_by":1,"id":"42995","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"42995"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00042995","sets":["1"]},"author_link":["427869","427860","427874","427863","427868","427861","427857","427856","427859","427870","427855","427853","427872","427858","427873","427867","427865","427871","427866","427875","427864","427862","427854"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"408","bibliographicPageStart":"405","bibliographicVolumeNumber":"99","bibliographic_titles":[{"bibliographic_title":"Radiation Protection Dosimetry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is well established that the RBE (relative biological effectiveness) for cell killing depends on LET (linear energy transfer), and that a maximum RBE is observed at  ~150 keV/mm.   However, the therapeutic gain depends on the ratio of the RBEs for the effects on the cancer cell population and the effects on normal tissues.    The RBE of a given radiation quality depends on LET but also on dose, biological system and effect, and irradiation conditions.   There is no data available to answer the question: which LET is suitable to improve the biological therapeutic gain of carbon ions?  Here, we selected 3 different LET values of 290 MeV/u carbon ions, and compared the relative biological effectiveness between tumor-growth retardation and skin damage using a murine transplantable tumor.   Larger RBE values for tumors after than the skin type were obtained when carbon-ions of intermediate LET were daily delivered for 2 through 5 fractions.   The biological therapeutic gain would be high for the carbon-ion SOBP if the number of fractions were correctly selected in clinical trials.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0144-8420","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koike, Sachiko"}],"nameIdentifiers":[{"nameIdentifier":"427853","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"427854","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uzawa, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"427855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takai, Nobuhiko"}],"nameIdentifiers":[{"nameIdentifier":"427856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukawa, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"427857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"427858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oohira, Chisa"}],"nameIdentifiers":[{"nameIdentifier":"427859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Mizuho"}],"nameIdentifiers":[{"nameIdentifier":"427860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Monobe, Manami"}],"nameIdentifiers":[{"nameIdentifier":"427861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lee, Ryonfa"}],"nameIdentifiers":[{"nameIdentifier":"427862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masao"}],"nameIdentifiers":[{"nameIdentifier":"427863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nojima, Kumie"}],"nameIdentifiers":[{"nameIdentifier":"427864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤 玲子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高井 伸彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427868","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"扶川 武志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427869","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427870","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 瑞穂","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427871","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"物部 真奈美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427872","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"李 玲華","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427873","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 雅雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427874","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野島 久美恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"427875","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Significance of fractionated irradiation for the biological therapeutic gain of carbon ions","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Significance of fractionated irradiation for the biological therapeutic gain of carbon ions"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-08-21"},"publish_date":"2002-08-21","publish_status":"0","recid":"42995","relation_version_is_last":true,"title":["Significance of fractionated irradiation for the biological therapeutic gain of carbon ions"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:32:30.617196+00:00"}