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Mapping adenosine A1 receptors in the cat brain by positron emission tomography with [11C] MPDX.
https://repo.qst.go.jp/records/42969
https://repo.qst.go.jp/records/42969faf4d447-09f2-485e-a623-83b17e7dda4d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-06-20 | |||||
| タイトル | ||||||
| タイトル | Mapping adenosine A1 receptors in the cat brain by positron emission tomography with [11C] MPDX. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shimada, Yuhei
× Shimada, Yuhei× Kiyosawa, Motohiro× Oda, Keiichi× Suzuki, Fumio× Ishiwata, Kiichi× Ogi, Nobuo× Hayakawa, Nobutaka× Umegaki, Hiroyuki× Nagaoka, Tsukasa× Endo, Kazutoyo× Tanaka, Akira× Senda, Michio× Nariai, Tadashi× Toyama, Hinako× Ono, Kenichirou× 織田 圭一× 石渡 喜一× 成相 直× 外山 比南子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We evaluated the potential of[11C]MPDX as a radioligand for mapping adenosine A1 receptors in comparison with previously proposed[11C]KF15372 in cat brain by PET, Two tracers showed the same brain distribution. Brain uptake of[11C]MPDX (Ki=4.2nM)was much higher and washed out faster than that of[11C]KF15372 (Ki=3.0nM),and was blocked by carrier-loading or displaced with an A1 antagonist. The regional A1 receptor distribution evaluated with kinetic analysis is consistent with that previously measured in vitro.[11C]MPDX PET has a potential for mapping adenosine A1 receptors in brain . | |||||
| 書誌情報 |
Nuclear Medicine and Biology 巻 29, p. 29-37, 発行日 2002 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
