@article{oai:repo.qst.go.jp:00042969, author = {Shimada, Yuhei and Kiyosawa, Motohiro and Oda, Keiichi and Suzuki, Fumio and Ishiwata, Kiichi and Ogi, Nobuo and Hayakawa, Nobutaka and Umegaki, Hiroyuki and Nagaoka, Tsukasa and Endo, Kazutoyo and Tanaka, Akira and Senda, Michio and Nariai, Tadashi and Toyama, Hinako and Ono, Kenichirou and 織田 圭一 and 石渡 喜一 and 成相 直 and 外山 比南子}, journal = {Nuclear Medicine and Biology}, month = {}, note = {We evaluated the potential of[11C]MPDX as a radioligand for mapping adenosine A1 receptors in comparison with previously proposed[11C]KF15372 in cat brain by PET, Two tracers showed the same brain distribution. Brain uptake of[11C]MPDX (Ki=4.2nM)was much higher and washed out faster than that of[11C]KF15372 (Ki=3.0nM),and was blocked by carrier-loading or displaced with an A1 antagonist. The regional A1 receptor distribution evaluated with kinetic analysis is consistent with that previously measured in vitro.[11C]MPDX PET has a potential for mapping adenosine A1 receptors in brain .}, pages = {29--37}, title = {Mapping adenosine A1 receptors in the cat brain by positron emission tomography with [11C] MPDX.}, volume = {29}, year = {2002} }