WEKO3
アイテム
{"_buckets": {"deposit": "bc44c2ac-3758-4202-93f0-dda2a71dd535"}, "_deposit": {"created_by": 1, "id": "42871", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "42871"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00042871", "sets": ["1"]}, "author_link": ["426723", "426719", "426725", "426721", "426722", "426724", "426718", "426727", "426728", "426720", "426726"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "174", "bibliographicPageStart": "165", "bibliographicVolumeNumber": "77", "bibliographic_titles": [{"bibliographic_title": "International Journal of Radiation Biology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "PURPOSE: To investigate initial chromatid breaks in prematurely condensed G2 chromosomes following exposure to heavy ions of different LET. MATERIAL AND METHODS: Exponentially growing human fibroblast cells AG1522 were irradiated with gamma-rays, energetic carbon (13 keV/ microm, 80 keV/microm), silicon (55 keV/microm) and iron (140 keV/microm, 185keV/microm, 440keV/microm) ions. Chromosomes were prematurely condensed using calyculin-A. Initial chromatid-type and isochromatid breaks in G2 cells were scored. RESULTS: The dose response curves for total chromatid breaks were linear regardless of radiation type. The relative biological effectiveness (RBE) showed a LET-dependent increase, peaking around 2.7 at 55-80keV/microm and decreasing at higher LET. The dose response curves for isochromatid-type breaks were linear for high-LET radiations, but linear-quadratic for gamma-rays and 13 keV/microm carbon ions. The RBE for the induction of isochromatid breaks obtained from linear components increased rapidly between 13keV/microm (about 7) and 80keV/microm carbon (about 71), and decreased gradually until 440 keV/microm iron ions (about 66). CONCLUSIONS: High-LET radiations are more effective at inducing isochromatid breaks, while low-LET radiations are more effective at inducing chromatid-type breaks. The densely ionizing track structures of heavy ions and the proximity of sister chromatids in G2 cells result in an increase in isochromatid breaks.", "subitem_description_type": "Abstract"}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0955-3002", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kawata, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "426718", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Durante, Marco"}], "nameIdentifiers": [{"nameIdentifier": "426719", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furusawa, Yoshiya"}], "nameIdentifiers": [{"nameIdentifier": "426720", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "George, Kerry"}], "nameIdentifiers": [{"nameIdentifier": "426721", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takai, Nobuhiko"}], "nameIdentifiers": [{"nameIdentifier": "426722", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "A, Cucinotta Francesca"}], "nameIdentifiers": [{"nameIdentifier": "426723", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "川田 哲也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "426724", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "古澤 佳也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "426725", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ジョージ ケリー", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "426726", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高井 伸彦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "426727", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "クシノッタ フランク", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "426728", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Dose-response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Dose-response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/42871", "pubdate": {"attribute_name": "公開日", "attribute_value": "2002-02-12"}, "publish_date": "2002-02-12", "publish_status": "0", "recid": "42871", "relation": {}, "relation_version_is_last": true, "title": ["Dose-response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions."], "weko_shared_id": -1}
Dose-response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions.
https://repo.qst.go.jp/records/42871
https://repo.qst.go.jp/records/42871a46302c6-045c-42da-bca3-cc459aa8595e
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2002-02-12 | |||||
タイトル | ||||||
タイトル | Dose-response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Kawata, Tetsuya
× Kawata, Tetsuya× Durante, Marco× Furusawa, Yoshiya× George, Kerry× Takai, Nobuhiko× A, Cucinotta Francesca× 川田 哲也× 古澤 佳也× ジョージ ケリー× 高井 伸彦× クシノッタ フランク |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: To investigate initial chromatid breaks in prematurely condensed G2 chromosomes following exposure to heavy ions of different LET. MATERIAL AND METHODS: Exponentially growing human fibroblast cells AG1522 were irradiated with gamma-rays, energetic carbon (13 keV/ microm, 80 keV/microm), silicon (55 keV/microm) and iron (140 keV/microm, 185keV/microm, 440keV/microm) ions. Chromosomes were prematurely condensed using calyculin-A. Initial chromatid-type and isochromatid breaks in G2 cells were scored. RESULTS: The dose response curves for total chromatid breaks were linear regardless of radiation type. The relative biological effectiveness (RBE) showed a LET-dependent increase, peaking around 2.7 at 55-80keV/microm and decreasing at higher LET. The dose response curves for isochromatid-type breaks were linear for high-LET radiations, but linear-quadratic for gamma-rays and 13 keV/microm carbon ions. The RBE for the induction of isochromatid breaks obtained from linear components increased rapidly between 13keV/microm (about 7) and 80keV/microm carbon (about 71), and decreased gradually until 440 keV/microm iron ions (about 66). CONCLUSIONS: High-LET radiations are more effective at inducing isochromatid breaks, while low-LET radiations are more effective at inducing chromatid-type breaks. The densely ionizing track structures of heavy ions and the proximity of sister chromatids in G2 cells result in an increase in isochromatid breaks. | |||||
書誌情報 |
International Journal of Radiation Biology 巻 77, p. 165-174, 発行日 2001 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0955-3002 |