{"created":"2023-05-15T14:33:04.103207+00:00","id":42871,"links":{},"metadata":{"_buckets":{"deposit":"bc44c2ac-3758-4202-93f0-dda2a71dd535"},"_deposit":{"created_by":1,"id":"42871","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"42871"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00042871","sets":["1"]},"author_link":["426723","426719","426725","426721","426722","426724","426718","426727","426728","426720","426726"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"174","bibliographicPageStart":"165","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE: To investigate initial chromatid breaks in prematurely condensed G2 chromosomes following exposure to heavy ions of different LET. MATERIAL AND METHODS: Exponentially growing human fibroblast cells AG1522 were irradiated with gamma-rays, energetic carbon (13 keV/ microm, 80 keV/microm), silicon (55 keV/microm) and iron (140 keV/microm, 185keV/microm, 440keV/microm) ions. Chromosomes were prematurely condensed using calyculin-A. Initial chromatid-type and isochromatid breaks in G2 cells were scored. RESULTS: The dose response curves for total chromatid breaks were linear regardless of radiation type. The relative biological effectiveness (RBE) showed a LET-dependent increase, peaking around 2.7 at 55-80keV/microm and decreasing at higher LET. The dose response curves for isochromatid-type breaks were linear for high-LET radiations, but linear-quadratic for gamma-rays and 13 keV/microm carbon ions. The RBE for the induction of isochromatid breaks obtained from linear components increased rapidly between 13keV/microm (about 7) and 80keV/microm carbon (about 71), and decreased gradually until 440 keV/microm iron ions (about 66). CONCLUSIONS: High-LET radiations are more effective at inducing isochromatid breaks, while low-LET radiations are more effective at inducing chromatid-type breaks. The densely ionizing track structures of heavy ions and the proximity of sister chromatids in G2 cells result in an increase in isochromatid breaks.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0955-3002","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawata, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"426718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Durante, Marco"}],"nameIdentifiers":[{"nameIdentifier":"426719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"426720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"George, Kerry"}],"nameIdentifiers":[{"nameIdentifier":"426721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takai, Nobuhiko"}],"nameIdentifiers":[{"nameIdentifier":"426722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A, Cucinotta Francesca"}],"nameIdentifiers":[{"nameIdentifier":"426723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川田 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"426724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"426725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ジョージ ケリー","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"426726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高井 伸彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"426727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"クシノッタ フランク","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"426728","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dose-response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dose-response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-02-12"},"publish_date":"2002-02-12","publish_status":"0","recid":"42871","relation_version_is_last":true,"title":["Dose-response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:33:57.138984+00:00"}