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Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy
https://repo.qst.go.jp/records/84784
https://repo.qst.go.jp/records/84784aec979cf-aa30-4db9-85ca-a066eabf7099
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-01-20 | |||||
| タイトル | ||||||
| タイトル | Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakashita, Tetsuya
× Sakashita, Tetsuya× Shojiro, Matsumoto× Watanabe, Shigeki× Hirofumi, Hanaoka (Gunma Univ)× Oshima, Yasuhiro× Ikoma, Yoko× Naoyuki, Ukon (Fukushima Med Univ)× Sasaki, Ichiro× Higashi, Tatsuya× Tetsuya, Higuchi (Gunma Univ)× Yoshito, Tsushima (Gunma Univ)× Ishioka, Noriko× Tetsuya, Sakashita× Shojiro, Matsumoto× Shigeki, Watanabe× Yasuhiro, Oshima× Yoko, Ikoma× Ichiro, Sasaki× Tatsuya, Higashi× Noriko, Ishioka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We derived a new formalism of the RAP dose conversion method at time t. In addition, we acquired a formula to determine the optimal timing of a single measurement of the percent injected dose/g, assuming the one-compartment model for biological clearance. We investigated the new formalism’s performance using a representative RAP coefficient with radioactive-decay weighting. Dose conversions by representative RAP coefficients predicted the true [211At]MABG absorbed doses with an error of 10% or less. The inverses of the representative RAP coefficients plotted at 4 h post-injection, which was the optimal timing reported in the previous work, were very close to the new inverses of the RAP coefficients 4 h post-injection. Next, the behavior of the optimal timing was analyzed by radiolabeled compounds with physical half-lives of 7.2 h and 10 d on various biological clearance half-lives. Behavior maps of optimal timing showed a tendency to converge to a constant value as the biological clearance half-life of a target increased. The areas of optimal timing for both compounds within a 5% or 10% prediction error were distributed around the optimal timing when the biological clearance half-life of a target was equal to that of the reference. Finally, an example of RAP dose conversion was demonstrated for [211At]MABG. | |||||
| 書誌情報 |
EJNMMI Physics 巻 8, p. 80, 発行日 2021-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2197-7364 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34897556 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/s40658-021-00425-z | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://ejnmmiphys.springeropen.com/articles/10.1186/s40658-021-00425-z | |||||
