{"created":"2023-05-15T15:02:31.787664+00:00","id":84784,"links":{},"metadata":{"_buckets":{"deposit":"96b81a3d-10fa-42da-a191-3ab5420cc221"},"_deposit":{"created_by":1,"id":"84784","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"84784"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00084784","sets":["1"]},"author_link":["1023031","1023028","1023039","1023032","1023037","1023035","1023038","1023036","1023034","1023033","1023040","1023042","1023027","1023024","1023025","1023043","1023041","1023026","1023030","1023029"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"80","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"EJNMMI Physics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We derived a new formalism of the RAP dose conversion method at time t. In addition, we acquired a formula to determine the optimal timing of a single measurement of the percent injected dose/g, assuming the one-compartment model for biological clearance.　We investigated the new formalism’s performance using a representative RAP coefficient with radioactive-decay weighting. Dose conversions by representative RAP coefficients predicted the true [211At]MABG absorbed doses with an error of 10% or less. The inverses of the representative RAP coefficients plotted at 4 h post-injection, which was the optimal timing reported in the previous work, were very close to the new inverses of the RAP coefficients 4 h post-injection. Next, the behavior of the optimal timing was analyzed by radiolabeled compounds with physical half-lives of 7.2 h and 10 d on various biological clearance half-lives. Behavior maps of optimal timing showed a tendency to converge to a constant value as the biological clearance half-life of a target increased. The areas of optimal timing for both compounds within a 5% or 10% prediction error were distributed around the optimal timing when the biological clearance half-life of a target was equal to that of the reference. Finally, an example of RAP dose conversion was demonstrated for [211At]MABG.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34897556","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s40658-021-00425-z","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://ejnmmiphys.springeropen.com/articles/10.1186/s40658-021-00425-z","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2197-7364","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakashita, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"1023024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shojiro, Matsumoto"}],"nameIdentifiers":[{"nameIdentifier":"1023025","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"1023026","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirofumi, Hanaoka (Gunma Univ)"}],"nameIdentifiers":[{"nameIdentifier":"1023027","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oshima, Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"1023028","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikoma, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"1023029","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naoyuki, Ukon (Fukushima Med Univ)"}],"nameIdentifiers":[{"nameIdentifier":"1023030","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Ichiro"}],"nameIdentifiers":[{"nameIdentifier":"1023031","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"1023032","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsuya, Higuchi (Gunma Univ)"}],"nameIdentifiers":[{"nameIdentifier":"1023033","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshito, Tsushima (Gunma Univ)"}],"nameIdentifiers":[{"nameIdentifier":"1023034","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishioka, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"1023035","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsuya, Sakashita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1023036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shojiro, Matsumoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1023037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeki, Watanabe","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1023038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuhiro, Oshima","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1023039","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoko, Ikoma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1023040","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichiro, Sasaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1023041","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuya, Higashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1023042","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noriko, Ishioka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1023043","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-20"},"publish_date":"2021-01-20","publish_status":"0","recid":"84784","relation_version_is_last":true,"title":["Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:12:02.063542+00:00"}