@article{oai:repo.qst.go.jp:00084784,
 author = {Sakashita, Tetsuya and Shojiro, Matsumoto and Watanabe, Shigeki and Hirofumi, Hanaoka (Gunma Univ) and Oshima, Yasuhiro and Ikoma, Yoko and Naoyuki, Ukon (Fukushima Med Univ) and Sasaki, Ichiro and Higashi, Tatsuya and Tetsuya, Higuchi (Gunma Univ) and Yoshito, Tsushima (Gunma Univ) and Ishioka, Noriko and Tetsuya, Sakashita and Shojiro, Matsumoto and Shigeki, Watanabe and Yasuhiro, Oshima and Yoko, Ikoma and Ichiro, Sasaki and Tatsuya, Higashi and Noriko, Ishioka},
 journal = {EJNMMI Physics},
 month = {Nov},
 note = {We derived a new formalism of the RAP dose conversion method at time t. In addition, we acquired a formula to determine the optimal timing of a single measurement of the percent injected dose/g, assuming the one-compartment model for biological clearance.　We investigated the new formalism’s performance using a representative RAP coefficient with radioactive-decay weighting. Dose conversions by representative RAP coefficients predicted the true [211At]MABG absorbed doses with an error of 10% or less. The inverses of the representative RAP coefficients plotted at 4 h post-injection, which was the optimal timing reported in the previous work, were very close to the new inverses of the RAP coefficients 4 h post-injection. Next, the behavior of the optimal timing was analyzed by radiolabeled compounds with physical half-lives of 7.2 h and 10 d on various biological clearance half-lives. Behavior maps of optimal timing showed a tendency to converge to a constant value as the biological clearance half-life of a target increased. The areas of optimal timing for both compounds within a 5% or 10% prediction error were distributed around the optimal timing when the biological clearance half-life of a target was equal to that of the reference. Finally, an example of RAP dose conversion was demonstrated for [211At]MABG.},
 title = {Nonclinical study and applicability of the absorbed dose conversion method with a single biodistribution measurement for targeted alpha-nuclide therapy},
 volume = {8},
 year = {2021}
}