WEKO3
アイテム
{"_buckets": {"deposit": "2106befd-448e-4aee-bcec-c3cbba5ad16c"}, "_deposit": {"created_by": 1, "id": "81181", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "81181"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00081181", "sets": ["1"]}, "author_link": ["1011732", "1011736", "1011733", "1011742", "1011739", "1011735", "1011741", "1011731", "1011730", "1011740", "1011737", "1011743", "1011745", "1011738", "1011744", "1011734"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "919", "bibliographicPageStart": "908", "bibliographicVolumeNumber": "61", "bibliographic_titles": [{"bibliographic_title": "Journal of Radiation Research "}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The feasibility and efficacy of hypofractionated salvage radiotherapy (HS-RT) for prostate cancer (PC) with biochemical recurrence (BR) after prostatectomy, and the usefulness of prostate-specific antigen (PSA) kinetics as a\npredictor of BR, were evaluated in 38 patients who received HS-RT without androgen deprivation therapy between May 2009 and January 2017. Their median age, PSA level and PSA doubling time (PSA-DT) at the start of HS-RT\nwere 68 (53–74) years, 0.28 (0.20–0.79) ng/ml and 7.7 (2.3–38.5) months, respectively. A total dose of 60 Gy in 20 fractions (three times a week) was three-dimensionally delivered to the prostate bed. After a median follow-up\nof 62 (30–100) months, 19 (50%) patients developed a second BR after HS-RT, but only 1 patient died before the last follow-up. The 5-year overall survival and BR-free survival rates were 97.1 and 47.4%, respectively. Late grade 2\ngastrointestinal and genitourinary morbidities were observed in 0 and 5 (13%) patients, respectively. The PSA level as well as pathological T-stage and surgical margin status were regarded as significant predictive factors for a second\nBR by multivariate analysis. BR developed within 6 months after HS-RT in 11 (85%) of 13 patients with a PSADT \u003c 10 months compared with 1 (17%) of 6 with a PSA-DT ≥ 10 months (median time to BR: 3 vs 14 months,\nP \u003c 0.05). Despite the small number of patients, our HS-RT protocol seems feasible, and PSA kinetics may be useful for predicting the risk of BR and determining the appropriate follow-up schedule.\n", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "32888035", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1093/jrr/rraa074", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://academic.oup.com/jrr/article/61/6/908/5901560", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1349-9157", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ishikawa, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "1011730", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Keiko Higuchi"}], "nameIdentifiers": [{"nameIdentifier": "1011731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaminuma, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "1011732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takezawa, Yutaka"}], "nameIdentifiers": [{"nameIdentifier": "1011733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Yoshitaka"}], "nameIdentifiers": [{"nameIdentifier": "1011734", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Toru Etsunaga"}], "nameIdentifiers": [{"nameIdentifier": "1011735", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kazushi Maruo"}], "nameIdentifiers": [{"nameIdentifier": "1011736", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Hidemasa"}], "nameIdentifiers": [{"nameIdentifier": "1011737", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubo, Nobuteru"}], "nameIdentifiers": [{"nameIdentifier": "1011738", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakano, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "1011739", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mikio Kobayashi"}], "nameIdentifiers": [{"nameIdentifier": "1011740", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hitoshi, Ishikawa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011741", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaminuma, Takuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011742", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hidemasa, Kawamura", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011743", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nobuteru, Kubo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011744", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takashi, Nakano", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011745", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy ", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy "}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/81181", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-12-03"}, "publish_date": "2020-12-03", "publish_status": "0", "recid": "81181", "relation": {}, "relation_version_is_last": true, "title": ["The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy "], "weko_shared_id": -1}
The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy
https://repo.qst.go.jp/records/81181
https://repo.qst.go.jp/records/81181371332c6-7114-40f3-8a4e-c9d672624b3d
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-12-03 | |||||
タイトル | ||||||
タイトル | The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Ishikawa, Hitoshi
× Ishikawa, Hitoshi× Keiko Higuchi× Kaminuma, Takuya× Takezawa, Yutaka× Saito, Yoshitaka× Toru Etsunaga× Kazushi Maruo× Kawamura, Hidemasa× Kubo, Nobuteru× Nakano, Takashi× Mikio Kobayashi× Hitoshi, Ishikawa× Kaminuma, Takuya× Hidemasa, Kawamura× Nobuteru, Kubo× Takashi, Nakano |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The feasibility and efficacy of hypofractionated salvage radiotherapy (HS-RT) for prostate cancer (PC) with biochemical recurrence (BR) after prostatectomy, and the usefulness of prostate-specific antigen (PSA) kinetics as a predictor of BR, were evaluated in 38 patients who received HS-RT without androgen deprivation therapy between May 2009 and January 2017. Their median age, PSA level and PSA doubling time (PSA-DT) at the start of HS-RT were 68 (53–74) years, 0.28 (0.20–0.79) ng/ml and 7.7 (2.3–38.5) months, respectively. A total dose of 60 Gy in 20 fractions (three times a week) was three-dimensionally delivered to the prostate bed. After a median follow-up of 62 (30–100) months, 19 (50%) patients developed a second BR after HS-RT, but only 1 patient died before the last follow-up. The 5-year overall survival and BR-free survival rates were 97.1 and 47.4%, respectively. Late grade 2 gastrointestinal and genitourinary morbidities were observed in 0 and 5 (13%) patients, respectively. The PSA level as well as pathological T-stage and surgical margin status were regarded as significant predictive factors for a second BR by multivariate analysis. BR developed within 6 months after HS-RT in 11 (85%) of 13 patients with a PSADT < 10 months compared with 1 (17%) of 6 with a PSA-DT ≥ 10 months (median time to BR: 3 vs 14 months, P < 0.05). Despite the small number of patients, our HS-RT protocol seems feasible, and PSA kinetics may be useful for predicting the risk of BR and determining the appropriate follow-up schedule. |
|||||
書誌情報 |
Journal of Radiation Research 巻 61, 号 6, p. 908-919, 発行日 2020-12 |
|||||
出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1349-9157 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32888035 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/jrr/rraa074 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://academic.oup.com/jrr/article/61/6/908/5901560 |