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PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide
https://repo.qst.go.jp/records/79914
https://repo.qst.go.jp/records/79914871ab41f-a221-4478-9e5c-0a66c5e28a9c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-24 | |||||
| タイトル | ||||||
| タイトル | PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kuan, Hu
× Kuan, Hu× Shang, Jingjie× Xie, Lin× Hanyu, Masayuki× Zhang, Yiding× Yang, Zhimin× Xu, Hao× Lu, Wang× Ming-Rong, Zhang× Kuan, Hu× Lin, Xie× Masayuki, Hanyu× Zhang, Yiding× Yang, Zhimin× Lu, Wang× Zhang, Ming-Rong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Vascular endothelial growth factor receptors (VEGFRs) are well recognized as significant biomarkers of tumor angiogenesis. Herein, we have developed a first-of-its-kind peptide-based VEGFR positron emission tomography (PET) tracer. The novel [64Cu]VEGF125–136 peptide possessed satisfactory radio-characteristics and showed good specificity for the visualization of VEGFR in various mouse models, in which the tumor-specific radioactivity uptake was highly correlated to the VEGFR expression level. Moreover, the tracer showed high tumor uptake (ca. 5.89 %ID/g at 20 min postinjection in B16F10 mice) and excellent pharmacokinetics, achieving the maximum imaging quality within 1 h after injection. These features convey [64Cu]VEGF125–136 as a promising, clinically translatable PET tracer for the imaging of tumor angiogenesis. | |||||
| 書誌情報 |
ACS Omega 巻 2020, 号 5, p. 8508-8514, 発行日 2020-04 |
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| 出版者 | ||||||
| 出版者 | ACS Publications | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2470-1343 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1021/acsomega.9b03953 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178340/ | |||||
