{"created":"2023-05-15T14:58:54.452358+00:00","id":79914,"links":{},"metadata":{"_buckets":{"deposit":"22b674f0-971d-49b6-bba8-49868cd8e2e1"},"_deposit":{"created_by":1,"id":"79914","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79914"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079914","sets":["1"]},"author_link":["925857","925858","925865","925851","925855","925850","925860","925864","925853","925856","925862","925859","925863","925861","925854","925852"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"8514","bibliographicPageStart":"8508","bibliographicVolumeNumber":"2020","bibliographic_titles":[{"bibliographic_title":"ACS Omega"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Vascular endothelial growth factor receptors (VEGFRs) are well recognized as significant biomarkers of tumor angiogenesis. Herein, we have developed a first-of-its-kind peptide-based VEGFR positron emission tomography (PET) tracer. The novel [64Cu]VEGF125–136 peptide possessed satisfactory radio-characteristics and showed good specificity for the visualization of VEGFR in various mouse models, in which the tumor-specific radioactivity uptake was highly correlated to the VEGFR expression level. Moreover, the tracer showed high tumor uptake (ca. 5.89 %ID/g at 20 min postinjection in B16F10 mice) and excellent pharmacokinetics, achieving the maximum imaging quality within 1 h after injection. These features convey [64Cu]VEGF125–136 as a promising, clinically translatable PET tracer for the imaging of tumor angiogenesis.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS Publications"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acsomega.9b03953","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178340/","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2470-1343","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuan, Hu"}],"nameIdentifiers":[{"nameIdentifier":"925850","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shang, Jingjie"}],"nameIdentifiers":[{"nameIdentifier":"925851","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Lin"}],"nameIdentifiers":[{"nameIdentifier":"925852","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanyu, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"925853","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding"}],"nameIdentifiers":[{"nameIdentifier":"925854","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yang, Zhimin"}],"nameIdentifiers":[{"nameIdentifier":"925855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xu, Hao"}],"nameIdentifiers":[{"nameIdentifier":"925856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lu, Wang"}],"nameIdentifiers":[{"nameIdentifier":"925857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"925858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"925859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"925860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Hanyu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"925861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"925862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yang, Zhimin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"925863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lu, Wang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"925864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"925865","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-04-24"},"publish_date":"2020-04-24","publish_status":"0","recid":"79914","relation_version_is_last":true,"title":["PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:45:54.715624+00:00"}