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Synthesis of astatinated amino acid derivatives via an organosilyl precursor
https://repo.qst.go.jp/records/74683
https://repo.qst.go.jp/records/74683a360acab-5962-4869-92b9-730d431dd67b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-03-13 | |||||
| タイトル | ||||||
| タイトル | Synthesis of astatinated amino acid derivatives via an organosilyl precursor | |||||
| タイトル | ||||||
| タイトル | 有機ケイ素前駆体を用いたアスタチン標識アミノ酸の合成 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
渡辺, 茂樹
× 渡辺, 茂樹× Azim, Mohammmad Anwar-Ul (バングラデシュ国立核医学関連科学研究所)× 西中, 一朗× 佐々木, 一郎× 大島, 康宏× 山田, 圭一(群馬大学)× 石岡, 典子× Watanabe, Shigeki× Nishinaka, Ichiro× Sasaki, Ichiro× Oshima, Yasuhiro× Ishioka, Noriko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Astatine-211 (At-211) labeled phenylalanine were directly synthesized from an organosilylprecursor, (p-trimethylsilyl)phenylalanine, as a feasible study for the targeted alpha therapy (TAT) using amino acid derivatives. At-211 was isolated by dry distillation and then eluted with chloroform (CHCl3) or methanol-N-chlorosuccinimide solution (MeOH-NCS). After evaporating At-211 eluent, the mixture of the organosilylprecursor, NCS, and At-211 was heated at 70 oC in trifluoroacetic acid for 10 min. HPLC analysis demonstrated that a single radioactive peak was observed at retention time identical to that of the corresponding radioiodinated phenylalanine. Radiochemical yield (RCY) of the astatinated phenylalanine was 75% (CHCl3) and 64% (MeOH-NCS), respectively. These results clearly showed that the desired compound was successfully synthesized from an organosilylprecursor. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第58回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2018-11-16 | |||||
| 日付タイプ | Issued | |||||
