{"created":"2023-05-15T14:54:57.360032+00:00","id":74683,"links":{},"metadata":{"_buckets":{"deposit":"87b1a209-3f84-432f-aed5-ab1b06eed8ce"},"_deposit":{"created_by":1,"id":"74683","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"74683"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00074683","sets":["10:29"]},"author_link":["909088","909082","909087","909086","909080","909085","909081","909078","909084","909077","909083","909079"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-11-16","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Astatine-211 (At-211) labeled phenylalanine were directly synthesized from an organosilylprecursor, (p-trimethylsilyl)phenylalanine, as a feasible study for the targeted alpha therapy (TAT) using amino acid derivatives.  At-211 was isolated by dry distillation and then eluted with chloroform (CHCl3) or  methanol-N-chlorosuccinimide solution (MeOH-NCS). After evaporating At-211 eluent, the mixture of the organosilylprecursor, NCS, and At-211 was heated at 70 oC in trifluoroacetic acid for 10 min. HPLC analysis demonstrated that a single radioactive peak was observed at retention time identical to that of the corresponding radioiodinated phenylalanine. Radiochemical yield (RCY) of the astatinated phenylalanine was  75% (CHCl3) and 64% (MeOH-NCS), respectively. These results clearly showed that the desired compound was successfully synthesized from an organosilylprecursor.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第58回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡辺, 茂樹"}],"nameIdentifiers":[{"nameIdentifier":"909077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Azim, Mohammmad Anwar-Ul (バングラデシュ国立核医学関連科学研究所)"}],"nameIdentifiers":[{"nameIdentifier":"909078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西中, 一朗"}],"nameIdentifiers":[{"nameIdentifier":"909079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木, 一郎"}],"nameIdentifiers":[{"nameIdentifier":"909080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大島, 康宏"}],"nameIdentifiers":[{"nameIdentifier":"909081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 圭一(群馬大学)"}],"nameIdentifiers":[{"nameIdentifier":"909082","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石岡, 典子"}],"nameIdentifiers":[{"nameIdentifier":"909083","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909084","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishinaka, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oshima, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909087","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishioka, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909088","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Synthesis of astatinated amino acid derivatives via an organosilyl precursor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of astatinated amino acid derivatives via an organosilyl precursor"},{"subitem_title":"有機ケイ素前駆体を用いたアスタチン標識アミノ酸の合成","subitem_title_language":"en"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-13"},"publish_date":"2019-03-13","publish_status":"0","recid":"74683","relation_version_is_last":true,"title":["Synthesis of astatinated amino acid derivatives via an organosilyl precursor"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:06:09.461957+00:00"}