@misc{oai:repo.qst.go.jp:00074683,
 author = {渡辺, 茂樹 and Azim, Mohammmad Anwar-Ul (バングラデシュ国立核医学関連科学研究所) and 西中, 一朗 and 佐々木, 一郎 and 大島, 康宏 and 山田, 圭一(群馬大学) and 石岡, 典子 and Watanabe, Shigeki and Nishinaka, Ichiro and Sasaki, Ichiro and Oshima, Yasuhiro and Ishioka, Noriko},
 month = {Nov},
 note = {Astatine-211 (At-211) labeled phenylalanine were directly synthesized from an organosilylprecursor, (p-trimethylsilyl)phenylalanine, as a feasible study for the targeted alpha therapy (TAT) using amino acid derivatives.  At-211 was isolated by dry distillation and then eluted with chloroform (CHCl3) or  methanol-N-chlorosuccinimide solution (MeOH-NCS). After evaporating At-211 eluent, the mixture of the organosilylprecursor, NCS, and At-211 was heated at 70 oC in trifluoroacetic acid for 10 min. HPLC analysis demonstrated that a single radioactive peak was observed at retention time identical to that of the corresponding radioiodinated phenylalanine. Radiochemical yield (RCY) of the astatinated phenylalanine was  75% (CHCl3) and 64% (MeOH-NCS), respectively. These results clearly showed that the desired compound was successfully synthesized from an organosilylprecursor., 第58回日本核医学会学術総会},
 title = {Synthesis of astatinated amino acid derivatives via an organosilyl precursor},
 year = {2018}
}