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Synthesis and evaluation of novel positron emission tomography probe for metabotropic glutamate receptor 5
https://repo.qst.go.jp/records/72942
https://repo.qst.go.jp/records/72942ff5330af-39ac-49f8-b716-916aded45ee5
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-09-19 | |||||
タイトル | ||||||
タイトル | Synthesis and evaluation of novel positron emission tomography probe for metabotropic glutamate receptor 5 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Ishii, Hideki
× Ishii, Hideki× Yamasaki, Tomoteru× Zhang, Yiding× Zhang, Ming-Rong× 石井 英樹× 山崎 友照× 張 一鼎× 張 明栄 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The novel highly potent biologically stable metabotropic glutamate receptor 5 (mGlu5) selective positron emission tomography (PET) probes, [11C]-3-fluoro-5-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile ([11C]FPTB) and [11C]-3-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile ([11C]PTB), have been developed using Pd-mediated [11C]cyanation of 2-(2-(3-bromo-5-fluorophenyl)-2H-tetrazol-5-yl)pyridine (Br-FPTB) or 2-(2-(3-bromophenyl)-2H-tetrazol-5-yl)pyridine (Br-PTB). The elaboration of the reaction conditions and evaluation of these 11C-labeled probes (([11C]FPTB) and ([11C]PTB)) will be discussed. | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | WMIC2018(World Molecular Imaging Congress)でのポスター発表 | |||||
発表年月日 | ||||||
日付 | 2018-09-15 | |||||
日付タイプ | Issued |