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Effects of E244D mutation of cardiac troponin T on the structure of thin filaments by small-angle x-ray scattering
https://repo.qst.go.jp/records/72460
https://repo.qst.go.jp/records/724608bdbb901-f80c-4342-b215-34afe233d63c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-09-25 | |||||
| タイトル | ||||||
| タイトル | Effects of E244D mutation of cardiac troponin T on the structure of thin filaments by small-angle x-ray scattering | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
松尾, 龍人
× 松尾, 龍人× 松尾龍人× 河野, 史明× 藤原, 悟× 松尾 龍人× 河野 史明× 藤原 悟 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In order to investigate the effects of a cardiomyopathy-causing mutation E244D of troponin (Tn) T on the structure of thin filaments, small-angle x-ray scattering measurements were carried out on bovine cardiac thin filaments, in which the endogenous Tn was exchanged with human cardiac Tn containing the wild-type (WT) or E244D mutant (MT) of TnT, in the –Ca2+ and +Ca2+ states. Analysis by model calculation shows that while there are no structural differences between the WT and MT in the –Ca2+ state, tropomyosin (Tm) of the MT moves closer to the fiber axis than that of the WT in the +Ca2+ state. Since Tm directly controls myosin binding, this change would modulate the force production process, leading to functional aberration reported for the E244D mutation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第55回日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2017-09-21 | |||||
| 日付タイプ | Issued | |||||
