WEKO3
アイテム
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Reaction of Melatonin with Free Radicals in a Protic Medium and the Mechanism
https://repo.qst.go.jp/records/70386
https://repo.qst.go.jp/records/70386686a908c-5264-442f-9f90-41f90281eeb7
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-01-24 | |||||
タイトル | ||||||
タイトル | Reaction of Melatonin with Free Radicals in a Protic Medium and the Mechanism | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Nakanishi, Ikuo
× Nakanishi, Ikuo× Kabir, ZOARDAR× Kamibayashi, Masato× Ohkubo, Kei× Kawashima, Tomonori× Matsumoto, Kenichiro× Fukuzumi, Shunichi× Ozawa, Toshihiko× Anzai, Kazunori× 中西 郁夫× カビル ゾーダー× 上林 將人× 川島 知憲× 松本 謙一郎 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Melatonin (N-acetyl-5-methoxytryptamine), a pineal hormone, is known to show efficient antioxidative activities. It is also known that melatonin significantly protects mice against whole-body X-ray irradiation. However, very little is known about the detailed mechanisms of such activities of melatonin. In this study, we demonstrate that melatonin scavenges galvinoxyl and 2,2-diphenyl-1-picrylhydrazyl radicals via an electron transfer from melatonin to the radicals rather than via a one-step hydrogen atom transfer in methanol. The kinetic data together with the calculated thermodynamic parameters obtained in this study provide a detailed mechanistic insight into the antioxidative activities of melatonin. | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Symposium on Free Radical Research: Contribution to Medicine | |||||
発表年月日 | ||||||
日付 | 2011-01-22 | |||||
日付タイプ | Issued |