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非小細胞肺癌症例における炭素イオン線治療前後の血清ペプチドーム解析
https://repo.qst.go.jp/records/69659
https://repo.qst.go.jp/records/696593ea7b2aa-9048-41b6-baaa-20ff1ddd2c2c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-12-19 | |||||
| タイトル | ||||||
| タイトル | 非小細胞肺癌症例における炭素イオン線治療前後の血清ペプチドーム解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
中嶋, 美緒
× 中嶋, 美緒× 梅村, 啓史× 馬場, 雅行× 須金, 紀雄× 山本, 直敬× 鎌田, 正× 溝江, 純悦× 辻井, 博彦× 朝長, 毅× 野村, 文夫× 中嶋 美緒× 馬場 雅行× 須金 紀雄× 山本 直敬× 鎌田 正× 溝江 純悦× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and Purpose: Carbon-ion radiotherapy (C-ion RT) for non-small cell lung cancer (NSCLC) is a low invasive therapy with good local control. But in less than 10% of all cases in-field local recurrence is ascertained. Additionally, grade 2 adverse reactions in lung or skin were observed in patients less than 5%. Because early assessment of these radioresistance and toxicity is valuable in C-ion RT, non-invasive and accurate biomarkers are required. Using peptidomic approach for serum samples from NSCLC patients, we aimed to discover biomarkers useful for monitoring responses of tumor and normal tissue after C-ion RT. Material and Method: We enrolled 30 NSCLC patients who underwent C-ion RT in our hospital from September, 2006 to August, 2007. Serum samples were collected from these patients before treatment and 1 day and 1, 3, 6 months after treatment. Then we prepared 5muL of serum with magnetic beads and profiled serum peptidome using MALDI-TOF MS( Bruker Daltonics Inc.). Result: Some peaks showed significant changes before and after treatment. Conclusion: These peaks have potentials to be novel biomarkers for monitoring therapeutic response or toxicity. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第67回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-10-30 | |||||
| 日付タイプ | Issued | |||||
