@misc{oai:repo.qst.go.jp:00069659,
 author = {中嶋, 美緒 and 梅村, 啓史 and 馬場, 雅行 and 須金, 紀雄 and 山本, 直敬 and 鎌田, 正 and 溝江, 純悦 and 辻井, 博彦 and 朝長, 毅 and 野村, 文夫 and 中嶋 美緒 and 馬場 雅行 and 須金 紀雄 and 山本 直敬 and 鎌田 正 and 溝江 純悦 and 辻井 博彦},
 month = {Oct},
 note = {Background and Purpose: Carbon-ion radiotherapy (C-ion RT) for non-small cell lung cancer (NSCLC) is a low invasive therapy with good local control. But in less than 10% of all cases in-field local recurrence is ascertained. Additionally, grade 2 adverse reactions in lung or skin were observed in patients less than 5%. Because early assessment of these radioresistance and toxicity is valuable in C-ion RT, non-invasive and accurate biomarkers are required. Using peptidomic approach for serum samples from NSCLC patients, we aimed to discover biomarkers useful for monitoring responses of tumor and normal tissue after C-ion RT. 
Material and Method: We enrolled 30 NSCLC patients who underwent C-ion RT in our hospital from September, 2006 to August, 2007. Serum samples were collected from these patients before treatment and 1 day and 1, 3, 6 months after treatment. Then we prepared 5muL of serum with magnetic beads and profiled serum peptidome using MALDI-TOF MS( Bruker Daltonics Inc.).
Result: Some peaks showed significant changes before and after treatment. Conclusion: These peaks have potentials to be novel biomarkers for monitoring therapeutic response or toxicity., 第67回日本癌学会学術総会},
 title = {非小細胞肺癌症例における炭素イオン線治療前後の血清ペプチドーム解析},
 year = {2008}
}