{"created":"2023-05-15T14:50:57.522177+00:00","id":69659,"links":{},"metadata":{"_buckets":{"deposit":"381af3fd-f6d2-481e-a2c3-5ddc4aa9f9ed"},"_deposit":{"created_by":1,"id":"69659","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69659"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069659","sets":["10:28"]},"author_link":["683790","683791","683796","683786","683800","683797","683788","683787","683789","683785","683794","683798","683792","683793","683799","683795","683784"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and Purpose: Carbon-ion radiotherapy (C-ion RT) for non-small cell lung cancer (NSCLC) is a low invasive therapy with good local control. But in less than 10% of all cases in-field local recurrence is ascertained. Additionally, grade 2 adverse reactions in lung or skin were observed in patients less than 5%. Because early assessment of these radioresistance and toxicity is valuable in C-ion RT, non-invasive and accurate biomarkers are required. Using peptidomic approach for serum samples from NSCLC patients, we aimed to discover biomarkers useful for monitoring responses of tumor and normal tissue after C-ion RT. \nMaterial and Method: We enrolled 30 NSCLC patients who underwent C-ion RT in our hospital from September, 2006 to August, 2007. Serum samples were collected from these patients before treatment and 1 day and 1, 3, 6 months after treatment. Then we prepared 5muL of serum with magnetic beads and profiled serum peptidome using MALDI-TOF MS( Bruker Daltonics Inc.).\nResult: Some peaks showed significant changes before and after treatment. Conclusion: These peaks have potentials to be novel biomarkers for monitoring therapeutic response or toxicity.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第67回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中嶋, 美緒"}],"nameIdentifiers":[{"nameIdentifier":"683784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"梅村, 啓史"}],"nameIdentifiers":[{"nameIdentifier":"683785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬場, 雅行"}],"nameIdentifiers":[{"nameIdentifier":"683786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須金, 紀雄"}],"nameIdentifiers":[{"nameIdentifier":"683787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 直敬"}],"nameIdentifiers":[{"nameIdentifier":"683788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"683789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江, 純悦"}],"nameIdentifiers":[{"nameIdentifier":"683790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井, 博彦"}],"nameIdentifiers":[{"nameIdentifier":"683791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"朝長, 毅"}],"nameIdentifiers":[{"nameIdentifier":"683792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野村, 文夫"}],"nameIdentifiers":[{"nameIdentifier":"683793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中嶋 美緒","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬場 雅行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須金 紀雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本 直敬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江 純悦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"683800","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"非小細胞肺癌症例における炭素イオン線治療前後の血清ペプチドーム解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"非小細胞肺癌症例における炭素イオン線治療前後の血清ペプチドーム解析"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-12-19"},"publish_date":"2008-12-19","publish_status":"0","recid":"69659","relation_version_is_last":true,"title":["非小細胞肺癌症例における炭素イオン線治療前後の血清ペプチドーム解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:11:54.157905+00:00"}