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Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterinecervix
https://repo.qst.go.jp/records/65007
https://repo.qst.go.jp/records/6500715d195b3-eb94-4b05-ba4f-15103b997b9a
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-23 | |||||
| タイトル | ||||||
| タイトル | Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterinecervix | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wakatuki, Masaru
× Wakatuki, Masaru× Kato, Shingo× Ohno, Tatsuya× Karasawa, Kumiko× Ando, Ken× Kiyohara, Hiroki× Irie, Daisuke× Nakano, Takashi× Kamada, Tadashi× Syozu, Makio× 若月 優× 加藤 眞吾× 唐澤 久美子× 安藤 謙× 入江 大介× 中野 隆史× 鎌田 正× 生水 真紀夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim: The authors performed phase I / II clinical trial to evaluate the toxicity and efficacy of carbon ion radiotherapy (C-ion RT) for locally advanced adenocarcinoma of the uterine cervix. Method: The treatment consisted of whole pelvic irradiation of 36.0 gray equivalents (GyE) with 12 fractions and extended local boost with dose escalation from 26.4GyE to 38.4GyE in 8 fractions. The dose escalation was performed with careful observation of acute normal tissue responses. Total dose to the cervical tumor was 62.4-74.4 GyE for 20 fractions. Results: Between April 1998 and February 2010, 55 patients were treated with C-ion RT in this clinical trial. The number of patients with stage IIB, IIIB, and IVA disease were 20, 33, and 2, respectively. Twenty-five of the 55 patients had pelvic lymph node metastases. Median tumor size was 5.5 cm (range, 3.0-11.8 cm). Histologically, 45 patients had adenocarcinoma and 10 patients had adenosquamous cell carcinoma. Overall treatment time ranged from 31 to 40 days with a median of 35 days. The median follow-up period for surviving and all patients were 66 and 37 months, respectively. Although 23 patients developed acute toxicity (G1-G2), all patients completed the treatment on schedule. Late toxicity was found in 19 patients whose toxicity observed was G1 or G2 except one with G4: G2 toxicity was detected 7 patients (12.7 %): 5 patients for bladder and 2 patients for small intestine. One patient had G4 rectal complication, which was surgically salvaged. Twenty-two patients (40.0 %) had local recurrence, 9 of which received salvage surgery, and 34 patients (61.8 %) had distant metastases. The 3-year local control rate, local control rate including salvage surgery and overall survival rate were 59.0 %, 72.3 % and 53.2 %, respectively. Conclusions: C-ion RT for adenocarcinoma of the uterine cervix was a safe treatment. Although the number of patients in this study was small, the results support continued investigation to confirm therapeutic efficacy. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Heavy Ion in Therapy and Space Radiation Symposium 2013(HITSRS2013) | |||||
| 発表年月日 | ||||||
| 日付 | 2013-05-18 | |||||
| 日付タイプ | Issued | |||||
