@misc{oai:repo.qst.go.jp:00065007,
 author = {Wakatuki, Masaru and Kato, Shingo and Ohno, Tatsuya and Karasawa, Kumiko and Ando, Ken and Kiyohara, Hiroki and Irie, Daisuke and Nakano, Takashi and Kamada, Tadashi and Syozu, Makio and 若月 優 and 加藤 眞吾 and 唐澤 久美子 and 安藤 謙 and 入江 大介 and 中野 隆史 and 鎌田 正 and 生水 真紀夫},
 month = {May},
 note = {Aim: The authors performed phase I / II clinical trial to evaluate the toxicity and efficacy of carbon ion radiotherapy (C-ion RT) for locally advanced adenocarcinoma of the uterine cervix. 
Method: The treatment consisted of whole pelvic irradiation of 36.0 gray equivalents (GyE) with 12 fractions and extended local boost with dose escalation from 26.4GyE to 38.4GyE in 8 fractions. The dose escalation was performed with careful observation of acute normal tissue responses. Total dose to the cervical tumor was 62.4-74.4 GyE for 20 fractions. 
Results: Between April 1998 and February 2010, 55 patients were treated with C-ion RT in this clinical trial. The number of patients with stage IIB, IIIB, and IVA disease were 20, 33, and 2, respectively. Twenty-five of the 55 patients had pelvic lymph node metastases. Median tumor size was 5.5 cm (range, 3.0-11.8 cm).  Histologically, 45 patients had adenocarcinoma and 10 patients had adenosquamous cell carcinoma. Overall treatment time ranged from 31 to 40 days with a median of 35 days. The median follow-up period for surviving and all patients were 66 and 37 months, respectively. Although 23 patients developed acute toxicity (G1-G2), all patients completed the treatment on schedule. Late toxicity was found in 19 patients whose toxicity observed was G1 or G2 except one with G4: G2 toxicity was detected 7 patients (12.7 %): 5 patients for bladder and 2 patients for small intestine. One patient had G4 rectal complication, which was surgically salvaged. Twenty-two patients (40.0 %) had local recurrence, 9 of which received salvage surgery, and 34 patients (61.8 %) had distant metastases. The 3-year local control rate, local control rate including salvage surgery and overall survival rate were 59.0 %, 72.3 % and 53.2 %, respectively. 
Conclusions: C-ion RT for adenocarcinoma of the uterine cervix was a safe treatment. Although the number of patients in this study was small, the results support continued investigation to confirm therapeutic efficacy., Heavy Ion in Therapy and Space Radiation Symposium 2013(HITSRS2013)},
 title = {Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterinecervix},
 year = {2013}
}