{"created":"2023-05-15T14:47:24.553677+00:00","id":65007,"links":{},"metadata":{"_buckets":{"deposit":"74145c39-d762-4c4d-8e56-fb19ce64d366"},"_deposit":{"created_by":1,"id":"65007","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"65007"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00065007","sets":["10:29"]},"author_link":["640550","640563","640555","640566","640557","640565","640556","640561","640549","640552","640554","640559","640564","640553","640562","640551","640560","640558"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-18","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: The authors performed phase I / II clinical trial to evaluate the toxicity and efficacy of carbon ion radiotherapy (C-ion RT) for locally advanced adenocarcinoma of the uterine cervix. \nMethod: The treatment consisted of whole pelvic irradiation of 36.0 gray equivalents (GyE) with 12 fractions and extended local boost with dose escalation from 26.4GyE to 38.4GyE in 8 fractions. The dose escalation was performed with careful observation of acute normal tissue responses. Total dose to the cervical tumor was 62.4-74.4 GyE for 20 fractions. \nResults: Between April 1998 and February 2010, 55 patients were treated with C-ion RT in this clinical trial. The number of patients with stage IIB, IIIB, and IVA disease were 20, 33, and 2, respectively. Twenty-five of the 55 patients had pelvic lymph node metastases. Median tumor size was 5.5 cm (range, 3.0-11.8 cm).  Histologically, 45 patients had adenocarcinoma and 10 patients had adenosquamous cell carcinoma. Overall treatment time ranged from 31 to 40 days with a median of 35 days. The median follow-up period for surviving and all patients were 66 and 37 months, respectively. Although 23 patients developed acute toxicity (G1-G2), all patients completed the treatment on schedule. Late toxicity was found in 19 patients whose toxicity observed was G1 or G2 except one with G4: G2 toxicity was detected 7 patients (12.7 %): 5 patients for bladder and 2 patients for small intestine. One patient had G4 rectal complication, which was surgically salvaged. Twenty-two patients (40.0 %) had local recurrence, 9 of which received salvage surgery, and 34 patients (61.8 %) had distant metastases. The 3-year local control rate, local control rate including salvage surgery and overall survival rate were 59.0 %, 72.3 % and 53.2 %, respectively. \nConclusions: C-ion RT for adenocarcinoma of the uterine cervix was a safe treatment. Although the number of patients in this study was small, the results support continued investigation to confirm therapeutic efficacy.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Heavy Ion in Therapy and Space Radiation Symposium 2013(HITSRS2013)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wakatuki, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"640549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"640550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohno, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"640551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Karasawa, Kumiko"}],"nameIdentifiers":[{"nameIdentifier":"640552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Ken"}],"nameIdentifiers":[{"nameIdentifier":"640553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiyohara, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"640554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"640555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"640556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"640557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Syozu, Makio"}],"nameIdentifiers":[{"nameIdentifier":"640558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若月 優","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 眞吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"唐澤 久美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 謙","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 大介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野 隆史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生水 真紀夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"640566","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterinecervix","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterinecervix"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-05-23"},"publish_date":"2013-05-23","publish_status":"0","recid":"65007","relation_version_is_last":true,"title":["Carbon ion Radiotherapy for locally advanced adenocarcinoma of the uterinecervix"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:05:06.949437+00:00"}